Abstract Infections are the main cause for delayed wound healing. Graphene oxide (GO) and cerium oxide nanoparticles are used for many biomedical applications because of their biocompatibility and therapeutic property. Cerium Oxide (CeO2)/Graphene Oxide (GO) nanocomposite was synthesized in this work. It shows good antimicrobial property against wound pathogens. The aggregation of CeO2 particles on GO results in the generation of reactive oxygen species (ROS) and inhibits microbial growth. The synthesized nanocomposites were analysed by X-ray diffraction, Transmission electron microscopy, Raman Spectroscopy, UV-vis diffuse reflectance spectroscopy and Fourier transformation-IR spectroscopy. The antimicrobial activity of CeO2/GO nanocomposite was tested against Escherichia coli (E.coli), Pseudomonas aeruginosa (P. aeruginosa) Staphylococcus aureus (S. aureus) and Salmonella typhi (S. typhi). Well diffusion method, growth curve studies, bio film inhibition studies and colony count studies were done in both presence and absence of visible light. The mechanistic investigation was done by the determination of reactive oxygen species (ROS), Lactate dehydrogenase leakage (LDH) assay and DNA fragmentation assay.

中文翻译：

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CeO2/GO 对伤口病原体的光诱导抗菌活性

摘要 感染是伤口愈合延迟的主要原因。氧化石墨烯 (GO) 和氧化铈纳米粒子因其生物相容性和治疗特性而被用于许多生物医学应用。在这项工作中合成了氧化铈 (CeO2)/氧化石墨烯 (GO) 纳米复合材料。它对伤口病原体显示出良好的抗菌性能。CeO2 颗粒在 GO 上的聚集导致活性氧 (ROS) 的产生并抑制微生物生长。通过 X 射线衍射、透射电子显微镜、拉曼光谱、紫外可见漫反射光谱和傅里叶变换红外光谱分析合成的纳米复合材料。测试了 CeO2/GO 纳米复合材料对大肠杆菌（E.coli）、铜绿假单胞菌（P. aeruginosa) 金黄色葡萄球菌 (S. aureus) 和伤寒沙门氏菌 (S. typhi)。孔扩散法、生长曲线研究、生物膜抑制研究和菌落计数研究在可见光存在和不存在的情况下进行。机理研究是通过测定活性氧 (ROS)、乳酸脱氢酶泄漏 (LDH) 测定和 DNA 片段化测定来完成的。