Elevated serum lactate concentration has been used to predict the risk of fatality in various disease states in acutely ill patients or poisoning with different chemicals. However, its utility in predicting disease progression during acute aflatoxicosis has not been investigated. This study was designed to evaluate changes in blood lactate levels following acute exposure to aflatoxin B₁ (AFB₁) and to determine whether changes in blood lactate levels bear any relationship with biochemical and/or morphological lesions in the stomach, duodenum, and liver. Twenty-one male Wistar rats were randomly divided into three groups (n = 7 rats /group) including Group A (control) receiving vehicle alone and Groups B and C treated with single oral doses of AFB₁ at 2.5 and 5 mg/kg, respectively. AFB₁ produced significant (p < 0.05) time- and dose-dependent increase in blood lactate concentration as early as 1 h following its administration, with further increases observed at 3 h and 6 h. The hyperlactatemia accompanied tissue oxidative changes including increased H₂O₂ and MDA, as well as depletion in glutathione, glutathione peroxidase, superoxide dismutase, and total thiols in gastro-duodenal and hepatic tissues. The oxidative changes were reflected in morphological alterations observed at histopathology with more severe lesions observed with the higher dose of AFB₁. Serum levels of pro-inflammatory cytokines (TNF-α and IL-1β) were, however, differently modified by AFB₁ administration. Taken together, the results from this study gives indication that hyperlactatemia may find utility in predicting the severity of tissue damage induced by acute AFB₁ exposure.

血清乳酸浓度的升高已被用于预测急性病患者各种疾病状态或使用不同化学药品中毒的死亡风险。但是，尚未研究其在预测急性黄曲霉毒素中毒过程中的作用。这项研究旨在评估急性暴露于黄曲霉毒素B ₁（AFB ₁）后血液乳酸水平的变化，并确定血液乳酸水平的变化是否与胃，十二指肠和肝脏的生化和/或形态学病变有任何关系。二十一雄性Wistar大鼠随机分成三组（Ñ = 7只大鼠/组），包括A组（对照）单独接受载体和组B和C用单口服剂量AFB的处理₁分别为2.5和5 mg / kg。最早在给药后1小时，AFB ₁产生显着（p <0.05）的时间和剂量依赖性血液乳酸浓度升高，在3 h和6 h观察到进一步升高。高脂血症伴随组织氧化变化，包括H ₂ O ₂和MDA增加，以及胃十二指肠和肝组织中谷胱甘肽，谷胱甘肽过氧化物酶，超氧化物歧化酶和总硫醇的消耗。氧化变化反映在组织病理学观察到的形态变化中，随着AFB ₁剂量的增加，病灶更严重。。但是，通过AFB ₁给药，血清促炎性细胞因子（TNF-α和IL-1β）的水平有所不同。两者合计，这项研究的结果表明，高乳酸血症可用于预测急性AFB ₁暴露引起的组织损伤的严重程度。