The genome of Saccharomyces cerevisiae – brewer’s or baker’s yeast – was the first eukaryotic genome to be sequenced in 1996. The identity of that yeast genome has been not just a product of sequencing, but also of its use after sequencing and particularly of its mobilization in scientific literature. We ask “what is the yeast genome?” as an empirical question by investigating “the yeast genome” as a discursive entity. Analyzing publications that followed sequencing points to several “yeast genomes” existing side-by-side: genomes as physical molecules, digital texts, and a historic event. Resolving this unified-yet-multiple “genome” helps make sense of contemporary developments in yeast genomics such as the synthetic yeast project, in which apparently “the same” genome occupies multiple roles and locations, and points to the utility of examining specific non-human genomes independent of the Human Genome Project.

中文翻译：

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酵母：一个细胞，一个参考序列，多个基因组？

Saccharomyces cerevisiae（啤酒酵母或面包酵母）的基因组是 1996 年第一个被测序的真核生物基因组。该酵母基因组的身份不仅是测序的产物，而且还在于它在测序后的使用，特别是它在科学文献。我们问“什么是酵母基因组？” 作为一个实证问题，通过将“酵母基因组”作为一个话语实体进行研究。分析测序后的出版物指出了几个并排存在的“酵母基因组”：基因组作为物理分子、数字文本和历史事件。解决这个统一但多重的“基因组”有助于理解酵母基因组学的当代发展，例如合成酵母项目，其中显然“相同”的基因组占据多个角色和位置，