Introduction: The study was conducted to determine the factors affecting the depression, family burden and depression status of families of children with Down syndrome.

Methods: This cross-sectional research was conducted with the mothers of 71 children with Down syndrome attending six special education and rehabilitation centers in Istanbul, Turkey that provide special education for children with Down syndrome. Data were collected using a sociodemographic information form, the Family Burden Assessment Scale for Families of Children with Intellectual Disability (FBAS) and the Beck Depression Inventory (BDI). Descriptive statistics, the Mann-Whitney U test, independent samples t-test, Kruskal Wallis test, One-way ANOVA, Pearson’s correlation, and multiple regression analysis were used for the data analysis.

Results: The mean age of the participating mothers was 41.59 ± 6.87 years; 93% were married and 56.3% had an education of 8 years or more. The mean BDI score in the study was 7.81 ± 6.92. According to FBAS, it was determined that 63.4% of the families felt a family burden. The mean BDI scores for mothers with a family burden were higher than among mothers without a family burden. The results of the regression analysis indicated that emotional burden and insufficiency perception were variables that significantly affected the depression status of the mothers. These variables account for 42% of the total variance for depression.

Conclusions: As a result of the research, it was determined that depression scores increased as the emotional load and sense of insufficiency increased for mothers of children with Down syndrome.

简介：该研究旨在确定影响唐氏综合症儿童抑郁症，家庭负担和家庭抑郁状况的因素。

方法：这项横断面研究是在土耳其伊斯坦布尔的六个特殊教育和康复中心对71名唐氏综合症儿童的母亲进行的，这些中心为唐氏综合症儿童提供特殊教育。使用社会人口统计学信息表，智障儿童家庭负担评估量表（FBAS）和贝克抑郁量表（BDI）收集数据。描述性统计，Mann-Whitney U检验，独立样本t检验，Kruskal Wallis检验，单向ANOVA，Pearson相关性和多元回归分析用于数据分析。

结果：参与研究的母亲的平均年龄为41.59±6.87岁；93％的已婚人士和56.3％的8年或以上的文化程度。该研究的平均BDI评分为7.81±6.92。根据FBAS，据确定有63.4％的家庭感到家庭负担。有家庭负担的母亲的平均BDI得分高于没有家庭负担的母亲。回归分析的结果表明，情绪负担和不足感是显着影响母亲抑郁状态的变量。这些变量占抑郁症总方差的42％。

结论：研究的结果表明，唐氏综合症患儿的母亲的抑郁量随着情绪负担和机能不全感的增加而增加。