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A MATHEMATICAL ANALYSIS OF ZIKA VIRUS EPIDEMIC IN RIO DE JANEIRO AS A VECTOR-BORNE AND SEXUALLY TRANSMITTED DISEASE
Journal of Biological Systems ( IF 1.3 ) Pub Date : 2019-02-08 , DOI: 10.1142/s0218339019500050
GUSTAVO CRUZ-PACHECO 1 , LOURDES ESTEVA 2 , CLAUDIA PIO FERREIRA 3
Affiliation  

In this work we formulate a mathematical model to assess the importance of sexual transmission during the Zika virus outbreak that occurred in Rio de Janeiro, Brazil, in 2015. To this end, we deduce from the model an analytical expression of the basic reproduction number of Zika, [Formula: see text], in terms of the vectorial and sexual transmissions, and we use the estimations given in Ref. 1 [Villela DAM, Bastos LS, de Carvalho LM, Cruz OG, Gomes MFC, Durovni B, Lemos MC, Saraceni V, Coelho FC, Codeço CT, Zika in Rio de Janeiro: Assessment of basic reproduction number and comparison with dengue outbreaks, Epidemiol Infect 145(8):1649–1657, 2017] for the [Formula: see text] values of Zika virus and dengue virus epidemics in Rio de Janeiro to evaluate the contribution of sexual transmission of Zika virus. According to the obtained results, sexual transmission (pure plus mediated by vector transmission) contributes from 23% to 46% for the [Formula: see text] increment. Also, an asymmetric sexual transmission between men and women can explain the fact that the incidence of Zika virus in women was 60% higher than in man during the 2015 epidemics. We also carry out a sensitivity analysis using [Formula: see text] as the output parameter. The results of this analysis have shown that the transmission rate between human and mosquito populations, the mosquito mortality rate, and the human infectious period are the parameters that contribute more to the [Formula: see text] variation, highlighting the importance of vector control to halt disease transmission.

中文翻译:

对里约热内卢寨卡病毒作为媒介传播和性传播疾病的流行的数学分析

在这项工作中,我们制定了一个数学模型来评估 2015 年在巴西里约热内卢发生的寨卡病毒爆发期间性传播的重要性。为此,我们从模型中推导出了基本繁殖数的解析表达式Zika,[公式:见正文],在矢量和性传播方面,我们使用参考文献中给出的估计。1 [Villela DAM、Bastos LS、de Carvalho LM、Cruz OG、Gomes MFC、Durovni B、Lemos MC、Saraceni V、Coelho FC、Codeço CT、里约热内卢的寨卡:评估基本繁殖数量并与登革热疫情进行比较, Epidemiol Infect 145(8):1649–1657, 2017],用于 [公式:见文本] 里约热内卢寨卡病毒和登革热病毒流行的价值,以评估寨卡病毒性传播的贡献。根据得到的结果,性传播(纯加通过媒介传播介导)对[公式:见正文]增量的贡献从 23% 到 46%。此外,男性和女性之间的不对称性传播可以解释这样一个事实,即 2015 年流行期间女性寨卡病毒的发病率比男性高 60%。我们还使用 [Formula: see text] 作为输出参数进行敏感性分析。该分析结果表明,人与蚊子种群之间的传播率、蚊子死亡率和人类传染期是导致[公式:见正文]变异的参数,突出了媒介控制对阻止疾病传播。男女之间的不对称性传播可以解释这样一个事实:在 2015 年流行期间,女性寨卡病毒的发病率比男性高 60%。我们还使用 [Formula: see text] 作为输出参数进行敏感性分析。该分析结果表明,人与蚊子种群之间的传播率、蚊子死亡率和人类传染期是导致[公式:见正文]变异的参数,突出了媒介控制对阻止疾病传播。男女之间的不对称性传播可以解释这样一个事实:在 2015 年流行期间,女性寨卡病毒的发病率比男性高 60%。我们还使用 [Formula: see text] 作为输出参数进行敏感性分析。该分析结果表明,人与蚊子种群之间的传播率、蚊子死亡率和人类传染期是导致[公式:见正文]变异的参数,突出了媒介控制对阻止疾病传播。
更新日期:2019-02-08
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