Introduction

Natural products derived from medicinal plants provide beneficial cancer chemotherapeutic drugs. Bioactive constituents from plants are explored for their anticancer properties.

Methods

Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J) were isolated from Taxus wallichiana. Compounds were screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR 2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell lines.

Results

Tasumatrol B showed good cytotoxic activity conducted for the improvement of inhibiting potential of these compounds against the cancer drug target protein (EGFR tyrosine kinase enzyme). The docking study showed that all compounds have binding affinities and interaction profile with the receptor tyrosine kinase.

Discussion

The study suggests that these compounds could be used for the discovery of novel inhibitors against the target receptors for the treatment of cancer.

中文翻译：

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Taxus wallichiana Zucc 紫杉类的体外和计算机体内抗癌潜力

介绍

源自药用植物的天然产物提供了有益的癌症化疗药物。探索来自植物的生物活性成分的抗癌特性。

方法

从红豆杉中分离出三种已知化合物（脱乙酰浆果赤霉素 III、tasumatrol B 和taxawallin J）。针对四种癌细胞系筛选化合物，例如 eA498、HepG2、NCI-H226 和 MDR 2780AD。使用针对癌细胞系的 MTT 测定评估细胞毒活性。

结果

Tasumatrol B 显示出良好的细胞毒活性，用于提高这些化合物对癌症药物靶蛋白（EGFR 酪氨酸激酶）的抑制潜力。对接研究表明，所有化合物都具有与受体酪氨酸激酶的结合亲和力和相互作用特征。

讨论

该研究表明，这些化合物可用于发现用于治疗癌症的靶受体的新型抑制剂。