Coronavirus disease (COVID-19), caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a huge impact on global human health and was declared a worldwide distributed pandemic by the World Health Organization. SARS-CoV-2 has strong transmission and pathogenicity; so far, there are more than 16,000,000 cases of infections around the world and COVID-19 has caused more than 656,000 deaths. Current data indicate risk factors of patients infected by SARS-CoV-2 are older age, male sex, and chronic underlying diseases such as hypertension, diabetes, cardiovascular diseases, chronic respiratory disease, and cancer. After the outbreak of COVID-19, concern whether transplant patients are more susceptible to SARS-CoV-2 has been raised. It is inconclusive whether patients after transplantation on chronic immunosuppressive therapy are more susceptible to developing a more severe disease course. There is limited literature mainly aimed at post-transplantation populations whose immunity was suppressive before the disease occurred. Therefore, we attempted to systematically introduce the characteristics of transplant recipients with COVID-19, immunology in SARS-CoV-2 infection, and potential therapeutic strategy.

中文翻译：

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SARS-CoV-2感染的移植患者的免疫学：传播，免疫应答和治疗策略。

由病毒重症急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的冠状病毒病（COVID-19）对全球人类健康产生了巨大影响，并被世界卫生组织宣布为全球性大流行病。SARS-CoV-2具有很强的传播力和致病性。到目前为止，全世界有超过1600万例感染病例，而COVID-19已导致656,000多例死亡。当前数据表明，感染SARS-CoV-2的患者的危险因素是年龄，男性和慢性基础疾病，例如高血压，糖尿病，心血管疾病，慢性呼吸道疾病和癌症。在COVID-19爆发后，人们开始担心移植患者是否更容易患SARS-CoV-2。接受慢性免疫抑制治疗的患者在移植后是否更容易患上更严重的疾病，尚无定论。有限的文献主要针对在疾病发生之前其免疫能力受到抑制的移植后人群。因此，我们试图系统地介绍COVID-19移植受者的特征，SARS-CoV-2感染的免疫学以及潜在的治疗策略。