The main objective of this work is to study the effect of blood pressure and viscosity on flow in a pathological and healthy anatomy. The method chosen for this project is the numerical simulation of fluid dynamics. First, a radiological database from Tlemcen hospital was studied in order to select a patient whose aortic anatomy is representative of the pathology studied in this research project. The left ventricle was segmented using SolidWork software. The exported data made it possible to model this geometry on Comsol software. The geometry has been idealized to make it comparable to a given healthy left ventricle geometry and present the main parameters which influence the ventricular hemodynamics. A first series of numerical simulations made it possible to highlight the hemodynamic disturbances associated with the pathology of interest and described extensively in the literature. A second series of numerical simulations made it possible to model the effect of blood viscosity on flow. All the results obtained, the modeling of the left ventricle, must be valid experimentally. This study therefore does not completely justify the treatment of ventricular dilation with a flow modulator but constitutes an important first step towards a proof of concept.

中文翻译：

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使用数值模型评估左心室充盈压力

这项工作的主要目的是研究血压和粘度对病理和健康解剖结构中流动的影响。该项目选择的方法是流体动力学的数值模拟。首先，研究了特莱姆森医院的放射学数据库，以选择一名主动脉解剖学代表本研究项目所研究病理学的患者。使用 SolidWork 软件分割左心室。导出的数据使得在 Comsol 软件上对这种几何形状进行建模成为可能。几何形状已被理想化，使其与给定的健康左心室几何形状相媲美，并呈现影响心室血流动力学的主要参数。第一系列数值模拟使得强调与感兴趣的病理相关的血流动力学紊乱成为可能，并在文献中进行了广泛描述。第二系列数值模拟使模拟血液粘度对流动的影响成为可能。所有获得的结果，左心室的建模，必须在实验上是有效的。因此，这项研究并不能完全证明用流量调节器治疗心室扩张是合理的，但它构成了迈向概念验证的重要第一步。