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Isothermal titration calorimetry: practical approaches and current applications in soft matter.
Soft Matter ( IF 2.9 ) Pub Date : 2020-09-18 , DOI: 10.1039/d0sm01345e
William R Archer 1 , Michael D Schulz 1
Affiliation  

Isothermal Titration Calorimetry (ITC) elucidates the thermodynamic profile (ΔH, ΔS, ΔG, Ka, and stoichiometry) of binding and dissociation reactions in solution. While ITC has primarily been used to investigate the thermodynamics of interactions between biological macromolecules and small molecules, it has become increasingly common for measuring binding interactions between synthetic polymers and small molecules, ions, or nanoparticles. This tutorial review describes applications of ITC in studying synthetic macromolecules and provides experimental guidelines for performing ITC experiments. We also highlight specific examples of using ITC to study soft matter, then discuss the limitations and the future of ITC in this field.

中文翻译:

等温滴定量热法:软物质的实用方法和当前应用。

等温滴定热量法(ITC)阐明了热力学曲线(ΔHΔSΔGK a和化学计量)在溶液中的结合和解离反应。尽管ITC主要用于研究生物大分子与小分子之间相互作用的热力学,但它已越来越普遍地用于测量合成聚合物与小分子,离子或纳米颗粒之间的结合相互作用。本教程概述描述了ITC在研究合成大分子中的应用,并提供了进行ITC实验的实验指南。我们还将重点介绍使用ITC研究软物质的具体示例,然后讨论ITC在该领域的局限性和未来。
更新日期:2020-10-07
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