Wound dressings able to deliver topically bioactive molecules represent a new generation of wound-regeneration therapies. In this article, foams based on methylcellulose cross-linked with Manuka honey were used as a platform to deliver borate bioactive glass particles doped additionally with copper. Borate bioactive glasses are of great interest in wound-healing applications due to a combination of favorable features, such as angiogenic and antibacterial properties. The multifunctional composite providing the dual effect of the bioactive glass and Manuka honey was produced by freeze-drying, and the resulting foams exhibit suitable morphology characterized by high porosity. Moreover, the performed tests showed improved wettability and mechanical performance with the addition of bioactive glass particles. Dissolution studies using simulated body fluid and cell biology tests using relevant skin cells further proved the excellent bioactivity and positive effects of the foams on cell...

中文翻译：

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麦卢卡蜂蜜和生物活性玻璃赋予甲基纤维素泡沫以抗菌作用，用于伤口愈合应用

能够传递局部生物活性分子的伤口敷料代表了新一代的伤口再生疗法。在这篇文章中，基于甲基纤维素与麦卢卡蜂蜜交联的泡沫被用作提供额外掺杂铜的硼酸盐生物活性玻璃颗粒的平台。硼酸盐生物活性玻璃由于结合了有利的特性，如血管生成和抗菌特性，在伤口愈合应用中引起了极大的兴趣。提供生物活性玻璃和麦卢卡蜂蜜双重作用的多功能复合材料是通过冷冻干燥生产的，所得泡沫呈现出具有高孔隙率特征的合适形态。此外，所进行的测试表明，添加生物活性玻璃颗粒可改善润湿性和机械性能。