Ginger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the production of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.

中文翻译：

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6-shogaol抑制L6肌肉细胞的氧化损伤

生姜（Zingiber Officinale Roscoe）可以减轻运动后的肌肉疼痛，而6-shogaol {（E）-1-（4-Hydroxy-3-methoxymethoxy）dec-4-en-3-one）}是主要必需品。姜中所含的油脂。在这项研究中，测量了6-shogaol对L6肌肉细胞抗氧化损伤的保护作用。6-shagol抑制了H2O2诱导的L6细胞损伤，并使细胞内HO-1和NRF2的mRNA和蛋白表达水平增加。6-松果酚还减少了细胞内ROS的产生。这些结果表明6-shagol有效抑制骨骼肌细胞的氧化损伤。