To investigate the correlation between family history of prostate cancer (PCa) and survival (overall and cancer specific) in patients undergoing treatment for PCa. ine thousand four hundred fifty-nine patients with PCa were extracted from the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database. Diagnosis occurred after 1998 and treatment before 2014. Cox proportional-hazards modeling was used to assess the effect of family history on overall survival after adjustment for confounders (age at diagnosis, NCCN risk category and year of treatment), and with stratification by primary treatment group. Competing risks regression modelling was used to assess PCa specific mortality. Men with a positive family history of PCa appear to have a lower Gleason score at the time of diagnosis (50% with Gleason < 7, compared to 39% in those without family history) and be diagnosed at a lower age (64 vs 69). Men with a positive family history of PCa appear to have better overall survival outcomes (p < 0.001, log rank test). In analysis adjusting for age at diagnosis, NCCN risk category and year of treatment, family history remained a significant factor when modelling overall survival (HR 0.72 95% CI 0.55–0.95, p = 0.021). There were no significant differences in treatment subgroups of radical prostatectomy (p = 0.7) and radiotherapy (0.054). Men with a positive family history of PCa appear to have better overall survival outcomes. This better survival may represent lead time bias and early initiation of PSA screening. Family history of PCa was not associated with different survival outcomes in men who were treated with either radical prostatectomy or radiotherapy.

中文翻译：

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前列腺癌家族史阳性的男性的生存结局：一项基于注册表的研究。

调查前列腺癌（PCa）家族史和接受PCa治疗的患者生存率（总体和癌症特异性）之间的相关性。从南澳大利亚州前列腺癌临床结果协作数据库（SA-PCCOC）中提取了459例PCa患者。诊断发生于1998年之后，2014年之前进行治疗。校正混杂因素（诊断时的年龄，NCCN风险类别和治疗年份）以及按主要治疗分层后，使用Cox比例风险模型评估家族史对总体生存的影响。组。竞争风险回归模型用于评估PCa的特定死亡率。诊断为PCa家族史阳性的男性格里森评分较低（格里森<7时为50％相比之下，没有家族病史的人中有39％的人）并且被诊断出年龄更低（64岁vs 69岁）。PCa家族史阳性的男性似乎具有更好的总体生存结局（p <0.001，对数秩检验）。在根据诊断时的年龄，NCCN风险类别和治疗年份进行调整的分析中，家族史仍然是模拟总体生存率的重要因素（HR 0.72 95％CI 0.55-0.95，p = 0.021）。根治性前列腺切除术（p = 0.7）和放疗（0.054）的治疗亚组无显着差异。患有PCa家族史阳性的男性似乎具有更好的总体生存结局。更好的生存率可能代表了前置时间偏差和PSA筛查的早期启动。