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Mixed Arylolefin/NHC Complexes of Platinum(II): Syntheses, Characterizations, and In Vitro Cytotoxicities
Organometallics ( IF 2.5 ) Pub Date : 2020-09-18 , DOI: 10.1021/acs.organomet.0c00450 Nguyen Thi Thanh Chi 1 , Van Thong Pham 1 , Han Vinh Huynh 2
Organometallics ( IF 2.5 ) Pub Date : 2020-09-18 , DOI: 10.1021/acs.organomet.0c00450 Nguyen Thi Thanh Chi 1 , Van Thong Pham 1 , Han Vinh Huynh 2
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Eight platinum(II) complexes of the formula [PtCl(arylolefin)(NHC)] (2–9) with varying NHCs and arylolefin chelators have been prepared and analyzed by spectroscopic and spectrometric methods. The study reveals that the binding of the arylolefins is influenced by remote ring substituents and by the NHC spectator ligands. A more strongly donating NHC exhibits an increased trans influence and weakens the olefinic donor notably, which could lead to its premature dissociation. Cytotoxicity studies on four human cancer cell lines indicate that a stronger binding of the arylolefin is more beneficial. The highest cytotoxic effects (IC50 = 0.18–0.70 μM) were observed for the complex [PtCl(Meug)(IMes)] (3), containing a more weakly donating NHC and the strongest arylolefin donor.
中文翻译：
铂（II）的混合芳烃/ NHC配合物：合成，表征和体外细胞毒性。
八个铂（II）下式的配合物[氯铂酸（芳基烯烃）（NHC）]（2 - 9）具有不同的NHCs和芳基烯烃螯合剂已被制备并通过光谱和光谱测定方法进行分析。研究表明，芳基烯烃的结合受远程环取代基和NHC观众配体的影响。给予更强的NHC表现出增加的反式影响，并显着削弱烯烃供体，这可能导致其过早解离。对四种人类癌细胞系的细胞毒性研究表明，芳基烯烃的更强结合更为有益。对于复合物[PtCl（Meug）（IMes）]观察到最高的细胞毒性作用（IC 50 = 0.18–0.70μM）（3），其中含有较弱的NHC和最强的芳基烯烃供体。
更新日期：2020-10-12
中文翻译：
铂（II）的混合芳烃/ NHC配合物：合成，表征和体外细胞毒性。
八个铂（II）下式的配合物[氯铂酸（芳基烯烃）（NHC）]（2 - 9）具有不同的NHCs和芳基烯烃螯合剂已被制备并通过光谱和光谱测定方法进行分析。研究表明，芳基烯烃的结合受远程环取代基和NHC观众配体的影响。给予更强的NHC表现出增加的反式影响，并显着削弱烯烃供体，这可能导致其过早解离。对四种人类癌细胞系的细胞毒性研究表明，芳基烯烃的更强结合更为有益。对于复合物[PtCl（Meug）（IMes）]观察到最高的细胞毒性作用（IC 50 = 0.18–0.70μM）（3），其中含有较弱的NHC和最强的芳基烯烃供体。
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