Background. Neuropilin 1 (NRP1) is involved in tumorigenesis, development, invasion, and metastasis by promoting angiogenesis of tumors. The study is aimed at evaluating the correlation between the expression of NRP1 protein and clinicopathological features of gastric cancer by meta-analysis. Methods. The published studies were searched in databases including CNKI, Wanfang, Chongqing VIP, Web of Science, and PubMed online. Clinical case studies were included to compare the correlation between NRP1 protein expression and clinicopathological characteristics of gastric cancer. The quality of the included literatures was evaluated by NOS scale. Meta-analysis was performed by Stata software to calculate the odds ratio (OR) and 95% confidence interval (CI). Results. A total of 12 studies were included in this analysis, involving 1,225 patients with gastric cancer. The analysis indicated that the expression of NRP1 protein in gastric cancer tissues was lower in the group of early stage versus advanced stage (, , ), tumor size less than 5 cm versus more than 5 cm (, , ), TNM stage I-II group versus stage III-IV patients (, , ), well to medium differentiation group versus poor differentiation group (, , ), and nonlymph node metastasis group versus lymph node metastasis group (, , ). The expression of NRP1 protein in gastric cancer was not related to gender, age, and Laurèn’s classification. Conclusion. The expression of NRP1 protein in gastric cancer is closely correlated to clinical stage, tumor size, TNM stage, differentiation, and lymph node metastasis.

中文翻译：

---

Neuropilin 1在胃癌中表达的临床病理学意义：一项荟萃分析

背景。Neuropilin 1 (NRP1) 通过促进肿瘤的血管生成参与肿瘤的发生、发展、侵袭和转移。本研究旨在通过荟萃分析评估NRP1蛋白表达与胃癌临床病理特征的相关性。方法。已发表的研究在CNKI、万方、重庆维普、Web of Science、PubMed等数据库进行在线检索。纳入临床病例研究，比较NRP1蛋白表达与胃癌临床病理特征的相关性。纳入文献质量采用NOS量表进行评价。采用Stata软件进行Meta分析，计算优势比（OR）和95%置信区间（CI）。结果。该分析共纳入 12 项研究，涉及 1,225 名胃癌患者。分析表明，早期组胃癌组织中NRP1蛋白的表达低于晚期组。, , )，肿瘤大小小于 5 cm 与大于 5 cm (, , ), TNM I-II 期组与 III-IV 期患者 (, , ），中分化组与分化差组（, , ),非淋巴结转移组与淋巴结转移组 (, , ）。NRP1蛋白在胃癌中的表达与性别、年龄、劳伦分型无关。结论。NRP1蛋白在胃癌中的表达与临床分期、肿瘤大小、TNM分期、分化程度、淋巴结转移等密切相关。