Objective: To evaluate symptoms of pediatric feeding disorders in a sample of individuals with 3q29 Deletion Syndrome. Previous research has found that individuals with 3q29 deletion syndrome (3q29Del) may experience elevated feeding concerns in early childhood; however, the specificity of these feeding concerns in this pediatric population is not well understood. Methods: We compared individuals with 3q29Del (n = 60) to matched controls (n = 59) using an 11-item survey that assessed commonly reported symptoms associated with pediatric feeding disorders. An exploratory analysis also examined individuals with 3q29Del with and without a comorbid autism spectrum disorder (ASD) diagnosis. Results: Caregivers of 3q29Del cases reported higher incidences of feeding concerns on all 11 items included in the survey. This included statistically significant differences in food refusal behaviors, rejection of one or more food group, and a history of failure to thrive. Parents of children with comorbid autism were more likely to report concerns regarding rejection of one or more food group compared to children with 3q29Del without autism. Conclusions: Results suggest individuals with 3q29Del experience increased symptoms of pediatric feeding disorders. Future research should include a more thorough multidisciplinary evaluation to further document the severity and identify optimal remediation strategies.

中文翻译：

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3q29缺失综合征患者的小儿进食障碍症状

目的：评估3q29缺失综合症患者样本中的小儿进食障碍症状。先前的研究发现，患有3q29缺失综合征（3q29Del）的人可能在幼儿期就出现了更高的摄食问题。然而，这些饮食问题在该儿科人群中的特异性尚不清楚。方法：我们使用一项11项调查，将3q29Del（n = 60）的个体与匹配的对照组（n = 59）进行了比较，该调查评估了通常报道的与小儿进食障碍有关的症状。一项探索性分析还检查了患有3q29Del且患有和未患有合并症的自闭症谱系障碍（ASD）诊断的个体。结果：3q29Del病例的护理人员报告，在调查中所有11个项目中，发生喂养担忧的发生率均较高。这包括拒绝食物行为，拒绝一种或多种食物的统计上的显着差异，以及to壮成长的历史。与没有自闭症的3q29Del儿童相比，合并自闭症儿童的父母更有可能报告对一种或多种食物的拒绝的担忧。结论：结果表明患有3q29Del的个体患儿进食障碍的症状增加。未来的研究应包括更全面的多学科评估，以进一步记录严重程度并确定最佳补救策略。与没有自闭症的3q29Del儿童相比，合并自闭症儿童的父母更有可能报告对一种或多种食物的拒绝的担忧。结论：结果表明患有3q29Del的个体患儿进食障碍的症状增加。未来的研究应包括更全面的多学科评估，以进一步记录严重程度并确定最佳补救策略。与没有自闭症的3q29Del儿童相比，合并自闭症儿童的父母更有可能报告对一种或多种食物的拒绝的担忧。结论：结果表明患有3q29Del的个体患儿进食障碍的症状增加。未来的研究应包括更全面的多学科评估，以进一步记录严重程度并确定最佳补救策略。