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The Recent Development of Hybridization Chain Reaction Strategies in Biosensors.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-09-18 , DOI: 10.1021/acssensors.0c01453
Chuyan Zhang 1 , Jing Chen 1 , Rui Sun 1 , Zhijun Huang 2 , Zewei Luo 2 , Chen Zhou 1 , Mengfan Wu 3 , Yixiang Duan 2, 3 , Yongxin Li 1, 4
Affiliation  

With the continuous development of biosensors, researchers have focused increasing attention on various signal amplification strategies to pursue superior performance for more applications. In comparison with other signal amplification strategies, hybridization chain reaction (HCR) as a powerful signal amplification technique shows its certain charm owing to nonenzymatic and isothermal features. Recently, on the basis of conventional HCR, this technique has been developed and improved rapidly, and a variety of HCR-based biosensors with excellent performance have been reported. Herein, we present a systematic and critical review on the research progress of HCR in biosensors in the last five years, including the newly developed HCR strategies such as multibranched HCR, migration HCR, localized HCR, in situ HCR, netlike HCR, and so on, as well as the combination strategies of HCR with isothermal signal amplification techniques, nanomaterials, and functional DNA molecules. By illustrating some representative works, we also summarize the advantage and challenge of HCR in biosensors, and offer a deep discussion of the latest progress and future development trends of HCR in biosensors.

中文翻译:

生物传感器杂交链反应策略的最新进展。

随着生物传感器的不断发展,研究人员将越来越多的注意力集中在各种信号放大策略上,以追求卓越的性能以用于更多应用。与其他信号放大策略相比,杂交链反应(HCR)作为一种强大的信号放大技术,由于其非酶和等温特性,显示出一定的魅力。近来,在常规HCR的基础上,该技术已经得到迅速发展和改进,并且已经报道了多种具有优异性能的基于HCR的生物传感器。在此,我们对生物传感器中HCR的研究进展进行了系统的,重要的回顾,包括最近开发的HCR策略,如多支HCR,迁移HCR,局部HCR,原位HCR,网状HCR等。 ,以及HCR与等温信号放大技术,纳米材料和功能性DNA分子的组合策略。通过举例说明一些有代表性的工作,我们还总结了HCR在生物传感器中的优势和挑战,并深入讨论了HCR在生物传感器中的最新进展和未来发展趋势。
更新日期:2020-10-25
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