Abstract

The origin of isolates routinely used by the community of Aspergillus fumigatus researchers is periodically a matter of intense discussion at our centre, as the construction of recombinant isolates have sometimes followed convoluted routes, the documentation describing their lineages is fragmented, and the nomenclature is confusing. As an aide memoir, not least for our own benefit, we submit the following account and tabulated list of strains (Table 1) in an effort to collate all of the relevant information in a single, easily accessible document. To maximise the accuracy of this record we have consulted widely amongst the community of Medical Mycologists using these strains. All the strains described are currently available from one of these organisations, namely the Fungal Genetics Stock Centre (FGSC), FungiDB, Ensembl Fungi and The National Collection of Pathogenic Fungi (NCPF) at Public Health England. Display items from this manuscript are also featured on FungiDB.

Lay abstract

We present a concise overview on the definition, origin and unique genetic makeup of the Aspergillus fumigatus isolates routinely in use by the fungal research community, to aid researchers to describe past and new strains and the experimental differences observed more accurately.

中文翻译：

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实验室常用烟曲霉分离株的谱系研究

摘要

烟曲霉研究人员经常使用的分离株的起源定期成为我们中心激烈讨论的问题，因为重组分离株的构建有时遵循复杂的路线，描述其谱系的文件支离破碎，命名也令人困惑。作为一份辅助回忆录，尤其是为了我们自己的利益，我们提交了以下说明和菌株列表（表 1），以便将所有相关信息整理在一个易于访问的文档中。为了最大限度地提高该记录的准确性，我们广泛咨询了使用这些菌株的医学真菌学家群体。目前描述的所有菌株均可从这些组织之一获得，即真菌遗传学库存中心 (FGSC)、FungiDB、Ensembl Fungi 和英国公共卫生国家病原真菌保藏中心 (NCPF)。这份手稿中的展示项目也出现在 FungiDB 上。

外行摘要

我们对真菌研究界常规使用的烟曲霉分离株的定义、起源和独特的基因组成进行了简要概述，以帮助研究人员更准确地描述过去和新的菌株以及观察到的实验差异。