Abstract

Candida albicans is a commensal yeast commonly found on the skin and in the body. However, in immunocompromised individuals, the fungi could cause local and systemic infections. The carbon source available plays an important role in the establishment of C. albicans infections. The fungi's ability to assimilate a variety of carbon sources plays a vital role in its colonization, and by extension, its fitness and pathogenicity, as it often inhabits niches that are glucose-limited but rich in alternative carbon sources. A difference in carbon sources affect the growth and mating of C. albicans, which contributes to its pathogenicity as proliferation helps the fungi colonize its environment. The carbon source also affects its metabolism and signaling pathways, which are integral parts of the fungi's fitness and pathogenicity. As a big percentage of the carbon assimilated by C. albicans goes to cell wall biogenesis, the availability of different carbon sources will result in cell walls with variations in rigidity, adhesion, and surface hydrophobicity. In addition to the biofilm formation of the fungi, the carbon source also influences whether the fungi grow in yeast- or mycelial-form. Both forms play different roles in C. albicans’s infection process. A better understanding of the role of the carbon sources in C. albicans’s pathogenicity would contribute to more effective treatment solutions for fungal infections.

中文翻译：

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白色念珠菌不同碳源的同化：适应性和致病性

摘要

白色念珠菌是一种常见于皮肤和体内的共生酵母。然而，在免疫功能低下的个体中，真菌会引起局部和全身感染。可用的碳源在白色念珠菌感染的建立中起着重要作用。真菌吸收各种碳源的能力在其定殖中起着至关重要的作用，进而影响其适应性和致病性，因为它经常栖息在葡萄糖受限但富含替代碳源的生态位中。碳源的差异影响白色念珠菌的生长和交配，这有助于其致病性，因为增殖有助于真菌在其环境中定居。碳源还影响其代谢和信号通路，这是真菌适应性和致病性的组成部分。由于白色念珠菌吸收的大部分碳进入细胞壁生物发生，因此不同碳源的可用性将导致细胞壁的刚度、粘附性和表面疏水性发生变化。除了真菌的生物膜形成之外，碳源还影响真菌是以酵母形式还是菌丝体形式生长。两种形式在白色念珠菌感染过程中发挥不同的作用。更好地了解碳源在白色念珠菌中的作用的致病性将有助于为真菌感染提供更有效的治疗解决方案。