Abstract

Organisms need to deal with the absolute requirement for metals and also their possible toxicity. This is achieved through an intricate network of signaling pathways that are integrated to ultimately fine-tune iron uptake and metabolism. The mechanisms by which plants cope with iron limitation and the associated genomic responses are well characterized. On top of this transcriptional cascade is another level of regulation involving the post-translational protein modification and degradation. The ubiquitination and/or degradation of several transcription factors in the iron-deficiency signaling pathways and metal transporters has recently come to light. In this review we discuss the mechanisms and possible roles of protein modification and turnover in the regulation of root iron-deficiency responses. We also highlight the tight coupling between metal sensing by E3 ubiquitin ligases or bifunctional transporters and protein degradation.

中文翻译：

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植物根缺铁反应中蛋白质泛素化和降解的许多方面

摘要

生物体需要处理对金属的绝对需求以及它们可能的毒性。这是通过一个复杂的信号通路网络实现的，这些信号通路被整合以最终微调铁的摄取和代谢。植物应对铁限制和相关基因组反应的机制已得到很好的表征。在这个转录级联之上是涉及翻译后蛋白质修饰和降解的另一级调节。最近发现了缺铁信号通路和金属转运蛋白中几种转录因子的泛素化和/或降解。在这篇综述中，我们讨论了蛋白质修饰和转换在调节根缺铁反应中的机制和可能的作用。