The urea cycle enzyme argininosuccinate synthase 1 (ASS1) is upregulated in some cancer types. A study now shows that tumor cells with elevated urea cycle activity due to high ASS1 expression enhance gluconeogenesis, enabling a metabolic shift toward serine synthesis and causing purine synthesis addiction for growth and proliferation.

中文翻译：

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ASS1igning 嘌呤依赖于癌症

尿素循环酶精氨琥珀酸合酶 1 (ASS1) 在某些癌症类型中上调。现在的一项研究表明，由于 ASS1 的高表达，具有升高的尿素循环活性的肿瘤细胞增强了糖异生，使代谢转变为丝氨酸合成，并导致嘌呤合成对生长和增殖成瘾。