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Current Perspectives on Therapies, Including Drug Delivery Systems, for Managing Glioblastoma Multiforme.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-18 , DOI: 10.1021/acschemneuro.0c00555 Mahendran Bhaskaran 1 , Vishakante Gowda Devegowda 1 , Vishal Kumar Gupta 1 , Amruthesh Shivachar 2 , Rohit Rajendra Bhosale 3 , Muthuraman Arunachalam 4 , Thirumalaraju Vaishnavi 5
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-09-18 , DOI: 10.1021/acschemneuro.0c00555 Mahendran Bhaskaran 1 , Vishakante Gowda Devegowda 1 , Vishal Kumar Gupta 1 , Amruthesh Shivachar 2 , Rohit Rajendra Bhosale 3 , Muthuraman Arunachalam 4 , Thirumalaraju Vaishnavi 5
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Glioblastoma multiforme (GBM), a standout among the most dangerous class of central nervous system (CNS) cancer, is most common and is an aggressive malignant brain tumor in adults. In spite of developments in modality therapy, it remains mostly incurable. Consequently, the need for novel systems, strategies, or therapeutic approaches for enhancing the assortment of active agents meant for GBM becomes an important criterion. Currently, cancer research focuses mainly on improving the treatment of GBM via diverse novel drug delivery systems. The treatment options at diagnosis are multimodal and include radiation therapy. Moreover, significant advances in understanding the molecular pathology of GBM and associated cell signaling pathways have opened opportunities for new therapies. Innovative treatment such as immunotherapy also gives hope for enhanced survival. The objective of this work was to collect and report the recent research findings to manage GBM. The present review includes existing novel drug delivery systems and therapies intended for managing GBM. Reported novel drug delivery systems and diverse therapies seem to be precise, secure, and relatively effective, which could lead to a new track for the obliteration of GBM.
中文翻译：
当前关于治疗胶质母细胞瘤的治疗方法的观点，包括药物输送系统。
多形胶质母细胞瘤（GBM）是最危险的中枢神经系统（CNS）类癌症中的佼佼者，它是成年人中最常见的恶性脑肿瘤。尽管在模态疗法方面有所发展，但仍几乎无法治愈。因此，需要新颖的系统，策略或治疗方法来增强用于GBM的活性剂的分类成为重要的标准。当前，癌症研究主要集中在通过多种新颖的药物递送系统改善GBM的治疗。诊断时的治疗选择是多模式的，包括放射治疗。而且，在理解GBM的分子病理学和相关的细胞信号传导途径方面的重大进展为新疗法打开了机会。免疫疗法等创新疗法也为提高生存率带来希望。这项工作的目的是收集和报告管理GBM的最新研究结果。本审查包括旨在管理GBM的现有新型药物输送系统和疗法。据报道，新颖的药物递送系统和多种疗法似乎是精确，安全且相对有效的，这可能会导致消除GBM的新轨道。
更新日期：2020-10-07
中文翻译：
当前关于治疗胶质母细胞瘤的治疗方法的观点，包括药物输送系统。
多形胶质母细胞瘤（GBM）是最危险的中枢神经系统（CNS）类癌症中的佼佼者，它是成年人中最常见的恶性脑肿瘤。尽管在模态疗法方面有所发展，但仍几乎无法治愈。因此，需要新颖的系统，策略或治疗方法来增强用于GBM的活性剂的分类成为重要的标准。当前，癌症研究主要集中在通过多种新颖的药物递送系统改善GBM的治疗。诊断时的治疗选择是多模式的，包括放射治疗。而且，在理解GBM的分子病理学和相关的细胞信号传导途径方面的重大进展为新疗法打开了机会。免疫疗法等创新疗法也为提高生存率带来希望。这项工作的目的是收集和报告管理GBM的最新研究结果。本审查包括旨在管理GBM的现有新型药物输送系统和疗法。据报道，新颖的药物递送系统和多种疗法似乎是精确，安全且相对有效的，这可能会导致消除GBM的新轨道。
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