Case Summary: 

A 61-year-old woman with ongoing tobacco use was referred to a colorectal surgery clinic after a screening colonoscopy found irregular lesions at the dentate line with biopsies revealing a high-grade squamous intraepithelial lesion. She reported scant bleeding and irregular bowel function, but no incontinence. She has a history of abnormal Papanicolaou tests, but has since undergone a hysterectomy and has no history of immunosuppressive treatment or HIV. She was taken for an examination under anesthesia that revealing a 2.5-cm mass in the anal canal and was biopsied. Pathological examination confirmed anal squamous cell carcinoma (ASCC) with strongly positive p16 staining. A CT of her chest, abdomen, and pelvis did not reveal metastatic disease. She was referred to medical and radiation oncology for radiation therapy with concurrent chemotherapy (5-fluorouracil (5-FU) and mitomycin C). Subsequent office examination with anoscopy 3 months after treatment demonstrated an anterior scar without residual tumor.

中文翻译：

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肛门鳞状细胞癌的诊断和治疗。

案例摘要： 

一名正在进行烟草使用的61岁妇女在结肠镜检查筛查发现齿状线上有不规则的病变并进行活检时发现结直肠上皮高度病变后，被转到了结直肠外科诊所。她报告出血少，肠功能不正常，但没有大小便失禁。她有Papanicolaou测试异常的病史，但此后接受了子宫切除术，也没有免疫抑制治疗或HIV病史。她在麻醉下接受检查，发现肛门管中有一个2.5厘米的肿块，并进行了活检。病理检查证实肛门鳞状细胞癌（ASCC）p16染色呈强阳性。胸部，腹部和骨盆的CT并未显示出转移性疾病。她被转诊至放射线医学和放射肿瘤学并发化疗（5-氟尿嘧啶（5-FU）和丝裂霉素C）。治疗后3个月，随后接受肛门镜检查办公室检查，发现前疤痕无残留肿瘤。