Abstract

Maca root extract on insulin, insulin receptor substrate-1 (IRS1), leptin, and NAD-dependent deacetylase sirtuin-1 (SIRT1), as well as body weight changes evaluated in this study for a 60 days model of normal and high-fat diet (HFD) fed rats. 28 male rats allocated to four groups: (i) Control, (ii) Maca (40 mg/kg/day), (iii) HFD, and (iv) HFD + Maca. After the 60 days of study, fat tissue and liver insulin levels decreased in the HFD and HFD + Maca groups in comparison to Control and Maca groups (p < .001). Maca group showed a significant IRS1 increase in the fat tissue (p < .0001). Leptin levels were the highest in the Maca group and the lowest in the HFD group in the fat tissue (p < .01). SIRT1 levels were found the highest in the Maca groups (p < .01). These results show the protective and regulatory effectiveness of Maca when fed with a normal or HFD diet.

摘要

玛卡根提取物对胰岛素、胰岛素受体底物-1 (IRS1)、瘦素和 NAD 依赖性脱乙酰酶 sirtuin-1 (SIRT1) 的影响，以及本研究中针对正常和高脂肪 60 天模型评估的体重变化饮食 (HFD) 喂养大鼠。28 只雄性大鼠被分配到四组：(i) 对照组，(ii) 玛卡（40 毫克/千克/天），(iii) HFD，和 (iv) HFD + 玛卡。60 天的研究后，与对照组和玛卡组相比，高脂饮食组和高脂饮食 + 玛卡组的脂肪组织和肝脏胰岛素水平有所降低 ( p  < .001)。玛卡组显示脂肪组织中的 IRS1 显着增加 ( p  < .0001)。在脂肪组织中瘦素水平在玛卡组中最高，在 HFD 组中最低 ( p  < .01)。SIRT1 水平在玛咖组中最高（p  < .01）。这些结果显示了在正常饮食或 HFD 饮食喂养时玛卡的保护和调节效果。