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Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets
Archives of Physiology and Biochemistry ( IF 2.5 ) Pub Date : 2020-09-19 , DOI: 10.1080/13813455.2020.1821064
Hasan Gencoglu 1
Affiliation  

Abstract

Maca root extract on insulin, insulin receptor substrate-1 (IRS1), leptin, and NAD-dependent deacetylase sirtuin-1 (SIRT1), as well as body weight changes evaluated in this study for a 60 days model of normal and high-fat diet (HFD) fed rats. 28 male rats allocated to four groups: (i) Control, (ii) Maca (40 mg/kg/day), (iii) HFD, and (iv) HFD + Maca. After the 60 days of study, fat tissue and liver insulin levels decreased in the HFD and HFD + Maca groups in comparison to Control and Maca groups (p < .001). Maca group showed a significant IRS1 increase in the fat tissue (p < .0001). Leptin levels were the highest in the Maca group and the lowest in the HFD group in the fat tissue (p < .01). SIRT1 levels were found the highest in the Maca groups (p < .01). These results show the protective and regulatory effectiveness of Maca when fed with a normal or HFD diet.



中文翻译:

玛卡调节正常和高脂肪饮食的大鼠的脂肪和肝脏能量代谢标志物胰岛素、IRS1、瘦素和 SIRT1

摘要

玛卡根提取物对胰岛素、胰岛素受体底物-1 (IRS1)、瘦素和 NAD 依赖性脱乙酰酶 sirtuin-1 (SIRT1) 的影响,以及本研究中针对正常和高脂肪 60 天模型评估的体重变化饮食 (HFD) 喂养大鼠。28 只雄性大鼠被分配到四组:(i) 对照组,(ii) 玛卡(40 毫克/千克/天),(iii) HFD,和 (iv) HFD + 玛卡。60 天的研究后,与对照组和玛卡组相比,高脂饮食组和高脂饮食 + 玛卡组的脂肪组织和肝脏胰岛素水平有所降低 ( p  < .001)。玛卡组显示脂肪组织中的 IRS1 显着增加 ( p  < .0001)。在脂肪组织中瘦素水平在玛卡组中最高,在 HFD 组中最低 ( p  < .01)。SIRT1 水平在玛咖组中最高(p  < .01)。这些结果显示了在正常饮食或 HFD 饮食喂养时玛卡的保护和调节效果。

更新日期:2020-09-19
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