Abstract

This study was conducted to determine the possible effects of long-term exogenous kisspeptin and its antagonist P234 on serum, liver and adipose tissue fatty acids (FA) profiles, as well as body weight, in female rats. Kisspeptin (50 pmol) and P234 (1 nmol) were administrated to the weaned Sprague–Dawley female rats by an intracerebroventricular injection from the 26th postnatal day to the 60th postnatal day. Percentages of the serum total saturated FA (∑SFA) and total monounsaturated FA (∑MUFA) were lower in the kisspeptin group. In the adipose tissue, ∑SFA was lower and total unsaturated FA higher in the P234 group. Moreover, long-term central kisspeptin injection caused a decrease in the body weight. When compared to the kisspeptin group, the final body weights were higher in the P234 and kisspeptin + P234 groups. According to our results, we suggest that kisspeptin has a regulatory role in FA metabolism and regulation of body weight.

摘要

本研究旨在确定长期外源性 kisspeptin 及其拮抗剂 P234 对雌性大鼠血清、肝脏和脂肪组织脂肪酸 (FA) 谱以及体重的可能影响。从出生后第 26 天到第 60 天，通过脑室内注射将 Kisspeptin (50 pmol) 和 P234 (1 nmol) 给予断奶的 Sprague-Dawley 雌性大鼠。kisspeptin 组的血清总饱和 FA (∑SFA) 和总单不饱和 FA (∑MUFA) 百分比较低。在脂肪组织中，P234 组的 ∑SFA 较低，总不饱和 FA 较高。此外，长期中枢kisspeptin注射导致体重下降。与 kisspeptin 组相比，P234 和 kisspeptin + P234 组的最终体重更高。根据我们的结果，