Abstract

Introduction

Cerebral ischemia causes muscle atrophy and motor incoordination in animals, impairing motor performance.

Objective

Thus, the objective of the present study was to analyze the motor performance and histomorphometry of the biceps brachii, soleus, and anterior tibialis muscles of rats submitted to a treadmill training program after induction of cerebral ischemia by the transient occlusion of the middle cerebral artery (MCAO).

Materials and Methods

To do so, twenty-four 30-day-old Wistar rats were utilized. The exercises were performed for 6 weeks on a leveled treadmill, for 30 min/day, 5 days a week, at a controlled speed of 8 m/min, and the MCAO surgery took place for 60 min. The animals were divided into the following experimental groups: SC (n = 6): control animals that underwent false surgery (operation without the induction of cerebral ischemia) and did not exercise (sedentary); CEA (n = 6): control animals exercised on the treadmill after the false surgery; SI (n = 6): sedentary ischemic animals; IEA (n = 6): animals exercised on the treadmill after the induction of cerebral ischemia.

Results

The type-II fibers atrophy in muscle soleo was observed in groups CEA (5125.63 ± 158.83) and SI (4982.38 ± 248.16) when compared to the SC (5927.98 ± 106.17) and IEA (6526.73 ± 195.08) groups.

Conclusion

It is concluded that the low intensity physical exercise performed on the treadmill for six weeks after the induction of cerebral ischemia by OMCA, promoted a decrease in the atrophy of muscles important of the ischemic animals, benefiting their motor performance.

中文翻译：

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脑缺血后运动大鼠骨骼肌运动性能及组织形态学分析

摘要

介绍

脑缺血导致动物肌肉萎缩和运动不协调，损害运动性能。

客观的

因此，本研究的目的是分析在大脑中动脉短暂闭塞诱发脑缺血后接受跑步机训练计划的大鼠肱二头肌、比目鱼肌和胫骨前肌的运动表现和组织形态学。民航组织）。

材料和方法

为此，使用了 24 只 30 天大的 Wistar 大鼠。练习在水平跑步机上进行 6 周，每天 30 分钟，每周 5 天，以 8 m/min 的受控速度进行，MCAO 手术进行 60 分钟。将动物分为以下实验组： SC（n  = 6）：进行假手术（未诱发脑缺血的手术）和不运动（久坐）的对照动物；CEA ( n  = 6)：假手术后在跑步机上锻炼的对照动物；SI ( n  = 6)：久坐的缺血动物；IEA ( n  = 6)：诱导脑缺血后在跑步机上锻炼的动物。

结果

与 SC (5927.98 ± 106.17) 和 IEA (6526.73 ± 195.08) 组相比，在 CEA (5125.63 ± 158.83) 和 SI (4982.38 ± 248.16) 组中观察到肌肉的 II 型纤维萎缩。

结论

得出的结论是，在 OMCA 诱导脑缺血后，在跑步机上进行六周的低强度体育锻炼，促进了缺血动物重要肌肉萎缩的减少，有利于它们的运动表现。