Abstract

Introduction

Lateral trunk flexion (LTF) is a common postural deformity in Parkinson’s disease (PD). Postural control is known to depend on visual, vestibular, and somatosensory information.

Objectives

This study aimed to investigate the relationship between vestibular dysfunction and postural abnormalities in PD patients with LTF.

Methods

We enrolled a total of 19 PD patients with LTF (PD-LTF+) and 19 age- and sex-matched PD patients without LTF (PD-LTF-). All patients underwent vestibular tests, including spontaneous nystagmus, gaze-evoked nystagmus, ocular movements, optokinetic eye test, fast positioning maneuvers, and the bithermal caloric test.

Results

Most of the PD-LTF + patients had abnormal vestibular function (11/19), while there were fewer vestibular function injuries in the control group (3/19). In PD-LTF + group, there were 5 patients (5/11, 45.5%) of peripheral vestibular dysfunction, 2 patients (2/11, 18.2%) of central vestibular damage, and 4 patients (4/11, 36.4%) of mixed injuries. The peripheral vestibular deficiencies could be either bilateral (4/9, 44.4%) or unilateral (5/9, 55.6%). The unilateral vestibular dysfunction was ipsilateral to the leaning side in 2 patients and contralateral to the leaning side in the other 3 patients.

Conclusion

Vestibular dysfunction may be an independent risk factor for LTF in PD patients.

中文翻译：

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帕金森病患者躯干侧屈与前庭功能障碍之间的联系：一项临床研究

摘要

介绍

躯干外侧屈曲 (LTF) 是帕金森病 (PD) 常见的体位畸形。众所周知，姿势控制依赖于视觉、前庭和体感信息。

目标

本研究旨在探讨 LTF PD 患者前庭功能障碍与姿势异常之间的关系。

方法

我们共招募了 19 名患有 LTF (PD-LTF+) 的 PD 患者和 19 名年龄和性别匹配的没有 LTF (PD-LTF-) 的 PD 患者。所有患者均接受了前庭测试，包括自发性眼球震颤、凝视诱发的眼球震颤、眼球运动、视动眼测试、快速定位动作和双温热量测试。

结果

大多数 PD-LTF + 患者的前庭功能异常（11/19），而对照组的前庭功能损伤较少（3/19）。PD-LTF+组外周前庭功能障碍5例（5/11，45.5%），中枢前庭损伤2例（2/11，18.2%），4例（4/11，36.4%）的混合伤害。外周前庭缺陷可能是双侧的（4/9, 44.4%）或单侧的（5/9, 55.6%）。2例患者单侧前庭功能障碍位于斜侧同侧，3例患者单侧前庭功能障碍位于斜侧对侧。

结论

前庭功能障碍可能是 PD 患者 LTF 的独立危险因素。