ABSTRACT

Introduction

Tuberculosis (TB) is a major health problem worldwide. The BCG, the only authorized vaccine to fight TB, shows a variable protection in the adult population highlighting the need of a new vaccine. Immunoinformatics offers a variety of tools that can predict immunogenic T-cell peptides of Mycobacterium tuberculosis (Mtb) that can be used to create a new vaccine. Immunoinformatics has made possible the identification of immunogenic T-cell peptides of Mtb that have been tested in vitro showing a potential for using these molecules as part of a new TB vaccine.

Areas covered

This review summarizes the most common immunoinformatics tools to identify immunogenic T-cell peptides and presents a compilation about research studies that have identified T-cell peptides of Mtb by using immunoinformatics. Also, it is provided a summary of the TB vaccines undergoing clinical trials.

Expert opinion

In the next few years, the field of peptide-based vaccines will keep growing along with the development of more efficient and sophisticated immunoinformatic tools to identify immunogenic peptides with a greater accuracy.

中文翻译：

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免疫信息学在开发针对结核分枝杆菌的基于T细胞肽的疫苗中的作用。

摘要

介绍

结核病（TB）是世界范围内的主要健康问题。卡介苗是唯一一种抗击结核病的授权疫苗，它在成年人群中显示出不同的保护作用，突出了对新疫苗的需求。免疫信息学提供了多种工具，可以预测结核分枝杆菌（Mtb）的免疫原性T细胞肽，从而可用于创建新疫苗。免疫信息学使鉴定Mtb的免疫原性T细胞肽成为可能，该肽已在体外进行了测试，显示出将这些分子用作新的TB疫苗的潜力。

覆盖区域

这篇综述总结了鉴定免疫原性T细胞肽的最常见的免疫信息学工具，并提供了有关使用免疫信息学鉴定了Mtb T细胞肽的研究的汇编。此外，还提供了正在进行临床试验的结核病疫苗的摘要。

专家意见

在未来几年中，基于肽的疫苗领域将随着不断发展的更高效，更先进的免疫信息学工具的发展而不断发展，以更准确地鉴定免疫原性肽。