Gram-negative phytopathogenic bacteria are a significant threat to food crops. These microbial invaders are responsible for a plethora of plant diseases and can be responsible for devastating losses in crops such as tomatoes, peppers, potatoes, olives, and rice. Current disease management strategies to mitigate yield losses involve the application of chemicals which are often harmful to both human health and the environment. Bacteriocins are small proteinaceous antibiotics produced by bacteria to kill closely related bacteria and thereby establish dominance within a niche. They potentially represent a safer alternative to chemicals when used in the field. Bacteriocins typically show a high degree of selectivity toward their targets with no off-target effects. This review outlines the current state of research on bacteriocins active against Gram-negative phytopathogenic bacteria. Furthermore, we will examine the feasibility of weaponizing bacteriocins for use as a treatment for bacterial plant diseases.

革兰氏阴性植物病原菌对粮食作物构成重大威胁。这些微生物入侵者会造成大量植物病害，并可能导致西红柿、辣椒、土豆、橄榄和水稻等农作物遭受毁灭性损失。当前减轻产量损失的疾病管理策略涉及使用通常对人类健康和环境有害的化学品。细菌素是细菌产生的小型蛋白质抗生素，可杀死密切相关的细菌，从而在生态位内建立优势地位。当在现场使用时，它们可能是化学品的更安全的替代品。细菌素通常对其靶点表现出高度选择性，并且没有脱靶效应。这篇综述概述了对革兰氏阴性植物病原菌具有活性的细菌素的研究现状。此外，我们将研究将细菌素武器化用于治疗细菌性植物病害的可行性。