Enantioseparation on Amino Alcohol‐Derived Stationary Phases by Supercritical Fluid Chromatography and High‐Performance Liquid Chromatograpy,Bulletin of the Korean Chemical Society

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Enantioseparation on Amino Alcohol‐Derived Stationary Phases by Supercritical Fluid Chromatography and High‐Performance Liquid Chromatograpy
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-09-18 , DOI: 10.1002/bkcs.12094
Gyuri Kim ₁ , Jae Jeong Ryoo ₂

Affiliation

Previous studies have shown that amino alcohol‐derived chiral stationary phases can effectively separate some chiral samples. With the aim at improving the chiral separation, in this study, the composition and type of the mobile phase and the particle size of the stationary phase are changed, and the analytical method is carried out in parallel using high‐performance liquid chromatograpy (HPLC) and supercritical fluid chromatography (SFC). By changing the type and composition of the mobile phase and reducing the particle size of the stationary phase, optimal separation and analysis conditions are obtained simultaneously for HPLC and SFC experiments. In particular, for a particle size of 3 μm, the resolution increases for dinitrobenzoyl phenylglycinol and 2,2,2‐trifluoro‐1‐(9‐anthryl)ethanol. Moreover, replacing the organic modifier from methanol to isopropanol allows obtaining better results in the SFC experiments of dinitrobenzoyl phenylglycinol, dinitrobenzoyl leucinol, and 2,2,2‐trifluoro‐1‐(9‐anthryl)ethanol GTOC,Chiral separation by SFC and HPLC.

中文翻译：

超临界液相色谱和高效液相色谱法对氨基醇衍生的固定相进行对映体分离

先前的研究表明，氨基醇衍生的手性固定相可以有效分离一些手性样品。为了改善手性分离，本研究改变了流动相的组成和类型以及固定相的粒径，并使用高效液相色谱法（HPLC）并行进行了分析方法。和超临界流体色谱（SFC）。通过改变流动相的类型和组成并减小固定相的粒径，可以同时为HPLC和SFC实验获得最佳的分离和分析条件。特别是对于3μm的粒径，二硝基苯甲酰基苯基甘醇和2,2,2-三氟-1-（9-蒽基）乙醇的分离度提高。此外，

更新日期：2020-09-20

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