Antihistamines, which are commonly used to treat allergic reactions, are known for their side effects, which contribute to weight gain. It is hypothesized that simultaneous Brillouin elastography and Raman spectroscopy can be used to detect changes in adipose tissue associated with a prolonged intake of desloratadine, a commonly used second generation antihistamine. White and brown adipose tissue samples were excised from adult rats following 16 weeks of daily administration of desloratadine. It was found that the prolonged intake of desloratadine leads to an increase in Brillouin shift in both adipose tissue types. Raman spectra indicate that antihistamine use reduces protein‐to‐lipid ratio in brown adipose tissue but not white adipose tissue, indicating the effect on adipose tissue is location‐dependent.

中文翻译：

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评估长期使用地氯雷他定对大鼠脂肪布里渊移动和组成的影响。

众所周知，通常用于治疗过敏反应的抗组胺药具有副作用，会增加体重。假设布里渊弹性成像和拉曼光谱同时进行可用于检测与长期服用地洛他定（一种常用的第二代抗组胺药）有关的脂肪组织变化。每天给予去氯雷他定16周后，从成年大鼠中切除白色和棕色脂肪组织样品。发现延长的去氯雷他定的摄入导致两种脂肪组织类型中的布里渊移位增加。拉曼光谱表明，使用抗组胺药可以降低棕色脂肪组织中蛋白质与脂质的比率，但不能降低白色脂肪组织中的蛋白质与脂质的比率，这表明对脂肪组织的影响取决于位置。