Meshes‐to‐Fibrils Transition of Gellan Gum Hydrogel Architecture by Thermal Annealing,Macromolecular Materials and Engineering

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Meshes‐to‐Fibrils Transition of Gellan Gum Hydrogel Architecture by Thermal Annealing
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2020-09-18 , DOI: 10.1002/mame.202000308
Anatolii A. Abalymov _{1,

2} , Louis Van der Meeren ₁ , Davy Van de Walle ₃ , Koen Dewettinck ₃ , Andre G. Skirtach ₁ , Bogdan V. Parakhonskiy ₁

Affiliation

The possibilities created by tuning the architecture of hydrogels open up extensive opportunities for their application in tissue engineering and biomedicine. A simple and effective procedure is developed here, based on thermal annealing, which affects the alignment of the fibrils and results in a mesh‐like structure. Atomic force microscopy and cryo‐scanning electron microscopy are used to characterize the resultant gel. The alignment angle is demonstrated to take place spontaneously, providing an easy way for self‐assembly of such structures. The protocol developed here is likely to be applicable in numerous areas of biomedicine and tissue engineering.

中文翻译：

热退火法对结冷胶水凝胶结构从网眼到原纤维的转变

通过调整水凝胶的结构所创造的可能性为其在组织工程和生物医学中的应用提供了广泛的机会。在此基础上，基于热退火开发了一种简单而有效的方法，该方法会影响原纤维的排列并形成网状结构。原子力显微镜和冷冻扫描电子显微镜用于表征所得凝胶。对准角被证明是自发发生的，为这种结构的自组装提供了一种简便的方法。这里开发的协议很可能适用于生物医学和组织工程的许多领域。

更新日期：2020-09-18

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