Polyether ether ketone (PEEK) has shown great promise for implant and biomedical applications because of its excellent chemical, mechanical, and biocompatible properties. However, PEEK is bioinert, which causes weak cell adhesion and limits its use for biomedical applications such as bone implants. Therefore, the activation of the PEEK's surface for cell attachment is desirable. In this study, oxygen plasma and gelatin were used to modify PEEK's surface and the effects of surface roughness, wettability, and cell adhesion to the surface were studied. Surface roughness was measured using a laser scanning confocal microscope, and wettability was measured using the sessile drop method. There was no significant difference in the roughness of the three samples. The gelatin‐coated surface showed higher wettability than the plasma‐modified or control samples. The cell attachment and proliferation rate were assessed by scanning electron microscopy and the XTT assay, respectively. The XTT assay results indicated that a greater number of cells grew on the gelatin‐coated PEEK surface than on the control or plasma‐treated surfaces. These results confirmed that the plasma and gelatin treatments enhanced the biocompatibility of the PEEK samples. The increase in biocompatibility could make PEEK a better material candidate for treating bone related injuries and defects.

中文翻译：

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用血浆和明胶对聚醚醚酮进行表面改性以增强细胞附着

聚醚醚酮 (PEEK) 因其优异的化学、机械和生物相容性而在植入物和生物医学应用中显示出巨大的前景。然而，PEEK 是生物惰性的，这会导致细胞粘附较弱，并限制其在骨植入等生物医学应用中的使用。因此，需要激活 PEEK 表面以进行细胞附着。在这项研究中，氧等离子体和明胶被用来修饰 PEEK 的表面，并研究了表面粗糙度、润湿性和细胞对表面的粘附性的影响。使用激光扫描共聚焦显微镜测量表面粗糙度，使用固滴法测量润湿性。三个样品的粗糙度没有显着差异。明胶涂层表面显示出比等离子体改性或对照样品更高的润湿性。分别通过扫描电子显微镜和XTT测定评估细胞附着率和增殖率。XTT 分析结果表明，与对照或等离子体处理的表面相比，在明胶涂层的 PEEK 表面上生长的细胞数量更多。这些结果证实，等离子体和明胶处理增强了 PEEK 样品的生物相容性。生物相容性的提高可以使 PEEK 成为治疗骨相关损伤和缺陷的更好材料候选者。XTT 分析结果表明，与对照或等离子体处理的表面相比，在明胶涂层的 PEEK 表面上生长的细胞数量更多。这些结果证实，等离子体和明胶处理增强了 PEEK 样品的生物相容性。生物相容性的提高可以使 PEEK 成为治疗骨相关损伤和缺陷的更好材料候选者。XTT 分析结果表明，与对照或等离子体处理的表面相比，在明胶涂层的 PEEK 表面上生长的细胞数量更多。这些结果证实，等离子体和明胶处理增强了 PEEK 样品的生物相容性。生物相容性的提高可以使 PEEK 成为治疗骨相关损伤和缺陷的更好材料候选者。