Childhood epilepsy with centrotemporal spikes (CECTS) is a common, focal, transient, developmental epilepsy syndrome characterized by unilateral or bilateral, independent epileptiform spikes in the Rolandic regions of unknown etiology. Given that CECTS presents during a period of dramatic white matter maturation and thatspikes in CECTS are activated during non–rapid eye movement (REM) sleep, we hypothesized that children with CECTS would have aberrant development of white matter connectivity between the thalamus and the Rolandic cortex. We further tested whether Rolandic thalamocortical structural connectivity correlates with spike rate during non‐REM sleep.

中文翻译：

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Rolandic 丘脑皮质白质回路持续异常的儿童癫痫伴中央颞区尖峰

伴有中心颞部棘波的儿童期癫痫 (CECTS) 是一种常见的、局灶性、暂时性、发育性癫痫综合征，其特征是在病因不明的 Rolandic 区域出现单侧或双侧、独立的癫痫样棘波。鉴于 CECTS 出现在白质剧烈成熟时期，并且 CECTS 中的尖峰在非快速眼动 (REM) 睡眠期间被激活，我们假设患有 CECTS 的儿童丘脑和 Rolandic 皮层之间的白质连接发育异常. 我们进一步测试了 Rolandic 丘脑皮质结构连接是否与非快速眼动睡眠期间的尖峰率相关。