Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against Phytomonas davidi (Kinetoplastea: Trypanosomatidae),Chemistry & Biodiversity

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Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against Phytomonas davidi (Kinetoplastea: Trypanosomatidae)
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-09-18 , DOI: 10.1002/cbdv.202000521
María Guzmán _{1,

2} , Azucena González-Coloma ₂ , María Fe Andrés ₂ , Juliana Navarro-Rocha ₃ , Rafael A Martínez-Díaz ₁

Affiliation

Eight essential oils (EOs) from selected medicinal plants have been tested for their activity against Phytomonas davidi, a plant trypanosomal parasite. In the present research, the EOs have been tested on promastigote forms of P. davidi ATCC® 30287™ strain, along with their major components, both separately and in binary combinations, using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) reduction assay. The EOs with the highest antipromastigote activity were from Origanum virens and Salvia lavandulifolia. Thymol and β‐pinene were the most active pure compounds. The study of the activity of the pure compounds in combination indicated the existence of antagonistic and synergistic effects depending on the concentration tested. In general, the combinations at low concentrations favored the activity.

中文翻译：

精选药用植物精油及其主要成分对 Phytomonas davidi (Kinetoplastea: Trypanosomatidae) 的生物学评价

已经测试了来自选定药用植物的八种精油 (EO) 对植物锥虫寄生虫 Phytomonas davidi 的活性。在本研究中，EO 已在 P. davidi ATCC® 30287™ 菌株的前鞭毛体形式及其主要成分上进行了测试，单独和二元组合，使用 3-(4,5-二甲基噻唑-2-yl )-2,5-二苯基溴化四唑 (MTT) 还原测定。具有最高抗前鞭毛体活性的 EO 来自牛至和丹参。百里酚和 β-蒎烯是活性最高的纯化合物。纯化合物组合活性的研究表明，根据测试浓度存在拮抗和协同作用。一般来说，低浓度的组合有利于活性。

更新日期：2020-09-18

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