1,3,4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities,Chemical Biology & Drug Design

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1,3,4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2020-09-18 , DOI: 10.1111/cbdd.13795
Ankur Vaidya ₁ , Devender Pathak ₁ , Kamal Shah ₂

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The 1,3,4‐oxadiazole nucleus is a biologically imperative scaffold possesses numerous biological activities. The broad and potent activity of 1,3,4‐oxadiazole and their derivatives has established them as important pharmacological scaffolds especially in the treatment of cancer disease. Several di‐, tri‐, aromatic, and heterocyclic substituted 1,3,4‐oxadiazole derivatives have been reported to possess potent anticancer activity. These substituted 1,3,4‐oxadiazoles had shown different mechanism of action and participated in anticancer drug discovery and development. This review is complementary to earlier reviews and aims to review the work reported on anticancer activities of 1,3,4‐oxadiazole derivatives from year 2000 to the beginning of 2020.

中文翻译：

1,3,4-恶二唑及其衍生物：抗癌活性最新进展综述

1,3,4-恶二唑核是一种生物学上必不可少的支架，具有多种生物学活性。1,3,4-恶二唑及其衍生物广泛而有效的活性使其成为重要的药理学支架，尤其是在治疗癌症疾病方面。据报道，几种二、三、芳族和杂环取代的 1,3,4-恶二唑衍生物具有有效的抗癌活性。这些取代的 1,3,4-恶二唑表现出不同的作用机制并参与了抗癌药物的发现和开发。本综述是对早期综述的补充，旨在回顾 2000 年至 2020 年初关于 1,3,4-恶二唑衍生物抗癌活性的报告工作。

更新日期：2020-09-18

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