Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consisting of “dissection” and “suture,” which correspond to differentiation and integration in a phase space, respectively. Then we introduce the surgical (pan-manifold) differential equation and solve several simple cases. In this way, we constructed “medical quantization” strategy which makes a bridge between quantum mechanics and molecular biology. As the application of this theory, here we describe a logical drug design methodology in detail, and its application to anti-prion drug design. Finally, we propose a plan for logical drug (and medical device) design center, in which all the necessary procedures could be done in one place.

在这里，我们描述了蛋白质手术的原理及其在调节蛋白质构象的分子设计中的应用。我们最初描述的Poincare对偶性定义了随时间变化的几何空间中互补性的基础。接下来，我们介绍由“解剖”和“缝合”组成的蛋白质外科手术理论，分别对应于相空间中的分化和整合。然后，我们介绍了外科（泛流形）微分方程，并解决了一些简单的情况。通过这种方式，我们构建了“医学量化”策略，从而在量子力学和分子生物学之间架起了一座桥梁。作为该理论的应用，在此我们详细描述一种合理的药物设计方法，并将其应用于抗-病毒药物设计。最后，