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Highly regioselective 1,3-dipolar cycloaddition of 3′-O-propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.tetlet.2020.152464 Muthian Shanmugasundaram 1 , Annamalai Senthilvelan 1 , Anilkumar R Kore 1
中文翻译：
3′-O-炔丙基鸟苷与氧化腈的高度区域选择性1,3-偶极环加成：一种合成含有异恶唑部分的鸟苷的有效方法
更新日期：2020-10-12
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.tetlet.2020.152464 Muthian Shanmugasundaram 1 , Annamalai Senthilvelan 1 , Anilkumar R Kore 1
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The 1,3-dipolar cycloaddition reaction of 3′-O-propargyl guanosine with various in-situ generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically important guanosine containing isoxazole moiety in good yields with high purities.
中文翻译：
3′-O-炔丙基鸟苷与氧化腈的高度区域选择性1,3-偶极环加成：一种合成含有异恶唑部分的鸟苷的有效方法
描述了在 DMF 作为溶剂的情况下，3'- O-炔丙基鸟苷与各种原位生成的氧化腈的 1,3-偶极环加成反应。值得注意的是，该反应具有高度区域选择性，能够以良好的收率和高纯度提供具有生物学重要意义的含有异恶唑部分的鸟苷。
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