Biosensors play a key role in almost every field of human activity – ranging from biomedical diagnosis and point-of-care health monitoring to environmental monitoring and forensics. Single-walled carbon nanotubes (SWCNTs) are one of the most promising materials for near-infrared (NIR) fluorescence-based biosensing. Herein, we develop a reusable, drop-casted, real-time optical biosensor based on peptide-encapsulated SWCNTs for the detection of low concentrations of acetic acid in the air, at room temperature. While detection of NIR signal usually requires expensive and bulky equipment, here we use the (6,5) SWCNTs chirality whose peak fluorescence lies within the range of 970 nm – 1050 nm, enabling the usage of low cost and compact silicon-based detectors. We demonstrate the detection of wine spoilage based on excess gaseous acetic acid using peptide-wrapped SWCNT sensors down to 0.05% (v/v) acetic acid concentrations. Our results open new avenues for gas phase detection using NIR fluorescent SWCNT nanosensors.

生物传感器在人类活动的几乎每个领域都发挥着关键作用-从生物医学诊断和即时医疗保健监视到环境监视和取证。单壁碳纳米管（SWCNT）是用于基于近红外（NIR）荧光的生物传感的最有前途的材料之一。在本文中，我们开发了一种基于肽封装的SWCNT的可重用的，直接投射的实时光学生物传感器，用于在室温下检测空气中的低浓度乙酸。虽然NIR信号的检测通常需要昂贵且笨重的设备，但在这里我们使用（6,5）SWCNTs手性，其峰值荧光在970 nm – 1050 nm范围内，从而可以使用低成本和紧凑的硅基检测器。我们演示了使用低至0.05％（v / v）乙酸浓度的肽包裹SWCNT传感器，基于过量气态乙酸检测葡萄酒变质的情况。我们的结果为使用NIR荧光SWCNT纳米传感器进行气相检测开辟了新途径。