Polyester-based composites with silica nanoparticles fillers are promising candidates as biomaterials due to improved mechanical and biological properties. However, nanofillers use generally leads to an inhomogeneous distribution inside the polymer matrix because of agglomeration, decreasing composites overall performances. In view of improving nanofillers dispersion, we developed a synthesis and characterization method to design poly(d,l-lactide)-grafted silica nanoparticles using “grafting to” method and to quantify the amount of grafted poly(d,l-lactide). Firstly, well-defined N-hydroxysuccinimide ester poly(d,l-lactide)s were synthesized through a new pathway. Then, amino-functionalized silica nanoparticles were grafted with those customized polyesters yielding an amide covalent bond between both reagents. Such PDLLA-grafted nanoparticles were precisely characterized and the grafting amount was quantified using a dual approach based on TGA and FTIR analysis. The synthesis and the characterization methods developed constitute a robust and reproducible way to design well-defined polymer-grafted silica nanoparticles that could be used as nanofillers in polymer matrix nanocomposites for biomedical applications.

具有改善的机械和生物性能的具有二氧化硅纳米粒子填料的聚酯基复合材料有望成为生物材料。然而，由于团聚，纳米填料的使用通常导致聚合物基体内的不均匀分布，从而降低了复合材料的整体性能。为了改善纳米填料的分散性，我们开发了一种合成和表征方法，以“接枝到”方法设计聚（d，1-丙交酯）接枝的二氧化硅纳米粒子，并定量了接枝的聚（d，1-丙交酯）的量。首先，定义明确的N-羟基琥珀酰亚胺酯聚（d，l-丙交酯通过新途径合成。然后，将氨基官能化的二氧化硅纳米粒子与那些定制的聚酯接枝，从而在两种试剂之间产生酰胺共价键。精确表征了这种PDLLA接枝的纳米颗粒，并使用基于TGA和FTIR分析的双重方法对接枝量进行了定量。所开发的合成方法和表征方法构成了设计可明确定义的聚合物接枝二氧化硅纳米颗粒的强大且可重现的方法，该纳米颗粒可用作生物医学应用的聚合物基质纳米复合材料中的纳米填料。