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Associations of attention distractibility with attention deficit and with variation in the KTN1 gene.
Neuroscience Letters ( IF 2.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.neulet.2020.135397
Iiris Tuvi 1 , Jaanus Harro 2 , Evelyn Kiive 1 , Mariliis Vaht 3 , Talis Bachmann 4
Affiliation  

Attention distractibility in a low load visual search experiment with a rare irrelevant distractor could be an objective continuous measure in adulthood that correlates well with the symptoms of attention deficit throughout lifespan. This was studied using a birth cohort representative sample in a longitudinal study. The expected correlations were not found between the distractor cost measured in the experiment in adulthood and the inattention questionnaire scores from ages 15-33. However, the coefficient of variability for RT (CVRT) correlated negatively with self-reported motor restlessness (age 15) and attention deficit (age 25). We suggest that hyperactivity in childhood improved motor control at age 33. Associations with the gene KTN1 rs945270 (found to affect putamen size) were explored. CVRT, motor restlessness at age 15 and attention deficit scores at age 25 were especially low for male C-allele carriers. A possible association with the volume of putamen of individual participants is considered.



中文翻译:

注意分心与注意缺陷和KTN1基因变异的关联。

低负荷视觉搜索实验中的注意力分散性(罕见的无关紧要的干扰物)可能是成年期的客观连续测量指标,与整个寿命期间的注意力不足症状密切相关。在纵向研究中使用出生队列代表样本对此进行了研究。在成年实验中测量的干扰因素成本与15-33岁的注意力不集中问卷得分之间未找到预期的相关性。但是,RT的变异系数(CVRT)与自我报告的运动不安(15岁)和注意力不足(25岁)负相关。我们建议儿童多动症可以改善33岁时的运动控制。与基因KTN1的关联rs945270(发现会影响壳大小)被探索。对于男性C等位基因携带者,CVRT,15岁时的运动不安和25岁时的注意力缺陷评分特别低。考虑与个体参与者的壳聚糖量可能的关联。

更新日期:2020-09-20
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