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Graphene oxide as broadband hyperthermic agent and chemo-photothermal dissolution of kidney-stone mimicking calcium oxalate crystals
Journal of Photochemistry and Photobiology A: Chemistry ( IF 4.1 ) Pub Date : 2020-09-18 , DOI: 10.1016/j.jphotochem.2020.112917
Hung-You Chen , Sandip Ghosh , Vinoth Kumar Ponnusamy , Surojit Chattopadhyay

Graphene oxide (GO) and gold nanorods (AuNRs) have been extensively evaluated for broadband (325-980 nm) photothermal (PT) heat generation and efficiency, on substrates having contrasting thermal conductivities. Infrared thermal imaging of the PT agents under broadband irradiation showed a maximum rise of local temperature of chicken kidney tissue by 16.4, and 5.7 °C for GO and AuNR, respectively, under similar irradiation conditions. The PT conversion efficiency, derived from the cooling curves of the dynamic PT response, was found to be exceeding 60 % for GO on chicken kidney tissue under 532, 785, and 980 nm laser irradiations. The PT effect was used to enhance the dissolution rate of the kidney stone mimicking calcium oxalate crystals in the presence of hydroxyanthraquinone (AQ) solution. Mass spectrometric experiments show that the combination of AQ and GO, when irradiated with 532 nm, could chemo-photothermally dissolve calcium oxalate by at least ∼20 % more than when using AQ alone, or using a resistive way of elevating the solution temperature.



中文翻译:

氧化石墨烯作为宽带高温剂和模拟草酸钙晶体的肾结石的化学光热溶解

氧化石墨烯(GO)和金纳米棒(AuNRs)已在具有相反热导率的基板上进行了宽带(325-980 nm)光热(PT)热产生和效率的广泛评估。PT试剂在宽带照射下的红外热成像显示,在相似的照射条件下,GO和AuNR分别使鸡肾组织的局部最高温度升高了16.4和5.7°C。由动态PT响应的冷却曲线得出的PT转换效率在532、785和980 nm的激光照射下,在鸡肾组织上的GO超过60%。在羟基蒽醌(AQ)溶液的存在下,PT效应可增强模拟草酸钙晶体的肾结石的溶解速率。

更新日期:2020-09-29
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