To identify biomarkers for multiple system atrophy-cerebellar type (MSA-C), we used flow cytometry to measure surface marker expression of peripheral blood monocytes from patients with MSA-C or hereditary spinocerebellar degeneration (hSCD) and from healthy controls (HCs). The percentage of intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs and showed significant positive correlations with disease duration and unified MSA rating scale scores. The percentage of CD62L+ intermediate monocytes was significantly lower in MSA-C patients than in hSCD patients and HCs. Early decrease of peripheral blood intermediate monocytes is characteristic of MSA-C and is a biomarker.

中文翻译：

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外周血中间单核细胞早期减少是多系统萎缩小脑型的特征

为了确定多系统萎缩-小脑型 (MSA-C) 的生物标志物，我们使用流式细胞术测量来自 MSA-C 或遗传性脊髓小脑变性 (hSCD) 患者和健康对照 (HC) 的外周血单核细胞的表面标志物表达。MSA-C 患者的中间单核细胞百分比显着低于 hSCD 患者和 HC，并且与病程和统一的 MSA 评分量表评分呈显着正相关。MSA-C 患者中 CD62L+ 中间单核细胞的百分比显着低于 hSCD 患者和 HC。外周血中间单核细胞的早期减少是 MSA-C 的特征，是一种生物标志物。