Abstract Natural heparin macromolecule has been widely used to improve the hemocompatibility of biomaterials. However, heparin can cause spontaneous bleeding in some patients, which is troublesome for clinical applications. Fortunately, analogous heparin polymers have shown promise to replace heparin. Here a new class of composite polyethersulfone (PES) membranes were constructed, which offered tunable permeability together with excellent hemocompatibility via incorporating heparin-mimicking semi-interpenetrating polymer. The polyurethane macromer was synthesized as an effective cross-linker to incorporate functional polyacrylic acid and poly-2-acrylanmido-2-methylpropanesulfonic acid segments into PES solution through in-situ cross-linking polymerization. Then the heparin-mimicking semi-interpenetrating composite PES membranes were fabricated from the resulting casting solution via alkali-induced phase separation technique. The resulting composite membranes showed excellent inhibition of protein adsorption, suppression of platelet adhesion, reduction of hemolysis ratio and prolongation of clotting times, while displayed high hydrophilicity, permeability and clearance to urea, creatinine and lysozyme. Interestingly, the composite membranes also exhibited excellent mechanical properties due to the synergistic effect of polyurethane composition and in-situ cross-linking copolymerization. To further demonstrate the applicability and effectiveness of this method, a composite PES hollow fiber with excellent ultrafiltration and mechanical properties was also fabricated. This straightforward and facile method is constructed as an ideal candidate to suppress blood clotting for a range of blood purification membrane-related applications.

中文翻译：

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具有多种优异性能的仿肝素半互穿复合膜用于有前景的血液透析

摘要 天然肝素大分子已被广泛用于改善生物材料的血液相容性。但是，肝素会导致部分患者自发性出血，给临床应用带来麻烦。幸运的是，类似的肝素聚合物已显示出替代肝素的前景。在这里构建了一类新的复合聚醚砜 (PES) 膜，它通过掺入模拟肝素的半互穿聚合物提供可调节的渗透性和优异的血液相容性。聚氨酯大分子单体被合成为一种有效的交联剂，通过原位交联聚合将功能性聚丙烯酸和聚-2-丙烯酰胺-2-甲基丙磺酸链段结合到 PES 溶液中。然后，通过碱诱导相分离技术，由所得浇铸溶液制备仿肝素半互穿复合 PES 膜。所得复合膜显示出优异的蛋白质吸附抑制、血小板粘附抑制、溶血率降低和凝血时间延长，同时显示出高亲水性、渗透性和对尿素、肌酐和溶菌酶的清除率。有趣的是，由于聚氨酯组合物和原位交联共聚的协同作用，复合膜还表现出优异的机械性能。为了进一步证明该方法的适用性和有效性，还制备了具有优异超滤和机械性能的复合 PES 中空纤维。