Abstract The electrochemical oxidation of an oxazolidinone class of antibiotic, Linezolid (LNZ) was studied in aqueous as well as aqueous/surfactant media on a commercially available boron-doped diamond (BDD) electrode pretreated cathodically. By using cyclic voltammetry, LNZ showed two couples of oxidation/reduction peak in aqueous solutions. The electrode process is pH-dependent and controlled by diffusion. The compound yielded two well-separated oxidation steps in acidic, neutral and alkaline media by employing square-wave voltammetry. The sensitivity of the voltammetric measurements was improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the electrolyte solution at pH 4.0. In Britton-Robinson buffer containing 0.9 mM CTAB, the calibration curves were linear for both oxidation peaks (Ia and IIa) over concentration ranges of 0.25–6.41 μg mL−1 (0.74–19.27 μM), with detection limits of 0.05 μg mL−1 (0.15 μM) for Ia, and 0.12 μg mL−1 (0.34 μM) for IIa. The practical applicability of developed methodology was tested in pharmaceutical formulations.

中文翻译：

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阴极预处理的掺硼金刚石电极在阳离子表面活性剂介质中测定恶唑烷酮类抗生素利奈唑胺的电化学和分析性能

摘要 在水和水/表面活性剂介质中，在阴极预处理的市售掺硼金刚石 (BDD) 电极上研究了恶唑烷酮类抗生素利奈唑胺 (LNZ) 的电化学氧化。通过循环伏安法，LNZ在水溶液中显示出两对氧化/还原峰。电极过程取决于 pH 值并由扩散控制。通过使用方波伏安法，该化合物在酸性、中性和碱性介质中产生了两个分离良好的氧化步骤。当电解质溶液中存在阳离子表面活性剂十六烷基三甲基溴化铵 (CTAB) 且 pH 值为 4.0 时，伏安测量的灵敏度得到提高。在含有 0.9 mM CTAB 的 Britton-Robinson 缓冲液中，在 0.25–6.41 μg mL-1 (0.74–19.27 μM) 的浓度范围内，两个氧化峰（Ia 和 IIa）的校准曲线都是线性的，Ia 的检测限为 0.05 μg mL-1 (0.15 μM) 和 0.12对于 IIa，μg mL-1 (0.34 μM)。在药物制剂中测试了所开发方法的实际适用性。