An eco-friendly polysaccharide (PSP001) isolated from the fruit rind of Punica granatum is a biodegradable polymer with immunostimulatory and anticancer properties. PSP001 was employed for the stimuli-responsive targeted delivery of antineoplastic agent doxorubicin (Dox) by the fabrication of Dox-holding PSP nanoparticles (DPN). The galactose moieties of PSP001 were occupied as an effective tumor-targeted motif against the over-expressed asialoglycoprotein and galectin receptors of cancers. DPN followed a pH-sensitive cargo release kinetics, competent cancer cell internalization profile, and appealing biocompatibility towards peripheral red blood cells. The selective execution of caspase-mediated programmed cell death by the DPN on cancer cells was confirmed with multiple apoptosis studies. Extensive toxicity profiling on BALB/c mice rules out any palpable signs of abnormality with DPN administration while bare Dox produced vital signs of toxicity. Studies on syngraft solid tumor-bearing mice uncovered the tumor homing nature of DPN with the subsequent release of the entrapped drug which further translated in the direction of a significant reduction in the tumor payload and enhanced survival benefits, thus offering a robust approach towards endurable cancer management.

从石榴皮的果皮中分离出的一种环保多糖（PSP001）是具有免疫刺激和抗癌特性的可生物降解的聚合物。PSP001通过制造持有Dox的PSP纳米粒子（DPN）来用于抗肿瘤药阿霉素（Dox）的刺激响应靶向递送。PSP001的半乳糖部分被用作针对癌症的过表达去唾液酸糖蛋白和半乳糖凝集素受体的有效肿瘤靶向基序。DPN遵循pH敏感的货物释放动力学，有效的癌细胞内化特性以及对外周血红细胞具有吸引力的生物相容性。DPN在癌细胞上选择性执行了caspase介导的程序性细胞死亡，这是通过多次凋亡研究证实的。对BALB / c小鼠进行广泛的毒性分析可排除DPN给药引起的任何明显异常迹象，而裸Dox则可产生重要的毒性迹象。同种移植实体瘤小鼠的研究揭示了DPN的肿瘤归巢性质，随后释放了被包埋的药物，这进一步转化为显着降低肿瘤有效载荷和提高生存率的方向，从而提供了一种持久的抗癌方法管理。