Recent evidence based studies have proposed hyaluronic acid (HA) as an emerging biopolymer for various tissue engineering application. Meanwhile, stem cells (SCs) have also gained immense popularity for their tissue regenerative capacity. Thus, combining HA and stem cells for tissue engineering application have shown to foster tissue repair and regeneration process. HA possesses the ability to interact with SCs via cellular surface receptors along with the capacity to elicit the process of differentiation. The influence of HA on stem cells has been widely investigated in cartilage and bone repair but their properties of reducing inflammation has also been explored in various other tissue repair processes. In this review, we have provided an insight to the effect of crosslinked and non-crosslinked HA on various stem cells. Further, HA based scaffolds combined with stem cells have shown to have a synergistic effect in the regeneration capacity. Also, various chemically modified HA and biomolecules conjugated HA as a suitable carrier or matrix for stem cells delivery and the effect of HA in fine tuning the stem cells function is discussed.

最近的基于证据的研究已提出透明质酸（HA）作为用于各种组织工程应用的新兴生物聚合物。同时，干细胞（SC）的组织再生能力也获得了极大的欢迎。因此，结合HA和干细胞用于组织工程应用已显示促进组织修复和再生过程。HA具有通过以下方式与SC进行交互的能力细胞表面受体以及引发分化过程的能力。HA对干细胞的影响已在软骨和骨修复中进行了广泛研究，但在其他组织修复过程中还探索了其减轻炎症的特性。在这篇综述中，我们提供了对交联和非交联HA对各种干细胞影响的见解。此外，HA基支架与干细胞结合已显示出对再生能力的协同作用。此外，还讨论了各种化学修饰的HA和缀合HA的生物分子，作为适合干细胞递送的载体或基质，以及HA在微调干细胞功能方面的作用。