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In situ decorated Au NPs on pectin-modified Fe3O4 NPs as a novel magnetic nanocomposite (Fe3O4/Pectin/Au) for catalytic reduction of nitroarenes and investigation of its anti-human lung cancer activities.
International Journal of Biological Macromolecules ( IF 8.2 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.ijbiomac.2020.09.102
Yun Li 1 , Na Li 2 , Wei Jiang 3 , Guoyuan Ma 1 , Mohammad Mahdi Zangeneh 4
Affiliation  

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NPs immobilized pectin modified magnetic nanoparticles (Fe3O4/Pectin/Au). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, XPS, VSM, XRD and ICP-OES. We investigated the chemical applications of the material in the catalytic reduction of nitroarenes using N2H4.H2O as the reducing agent in the EtOH/H2O solvent without any promoters or ligands. Due to strong paramagnetism, the catalyst was easily recovered and reused in 11 cycles without considerable leaching or loss in reactivity. The green protocol involves several advantages like mild conditions, easy workup, high yields, and reusability of the catalyst. Furthermore, the desired nanocomposite was employed in biological studies like anti-oxidant assay by DPPH radical scavenging test. Subsequently, on exhibiting a good IC50 value in the DPPH assay, we extended the bio-application of the Fe3O4/Pectin/Au in the anticancer study of adenocarcinoma cells of human lungs using three cancer cell lines, PC-14, LC-2/ad and HLC-1 and a normal cell line HUVEC. The best result was accomplished in PC-14 cell lines with the lowest IC50 values.



中文翻译:

在果胶修饰的Fe3O4 NPs上原位修饰的Au NPs是一种新颖的磁性纳米复合材料(Fe3O4 / Pectin / Au),用于催化还原硝基芳烃并研究其抗人肺癌活性。

近年来,绿色合成的纳米磁性生物复合材料已经发展成为具有巨大潜力的未来催化剂。这鼓励了我们设计和合成新型的Au Au NPs固定的果胶改性磁性纳米颗粒(Fe 3 O 4 / Pectin / Au)。使用诸如FT-IR,FESEM,TEM,EDX,XPS,VSM,XRD和ICP-OES之类的先进分析技术对其进行了精心表征。我们研究了该材料在N 2 H 4 .H 2 O作为EtOH / H 2中的还原剂催化还原硝基芳烃的化学应用。没有任何促进剂或配体的溶剂。由于强顺磁性,催化剂很容易回收并在11个循环中重复使用,而没有明显的浸出或反应性损失。绿色方案具有几个优点,例如温和的条件,易于后处理,高收率和催化剂的可重复使用性。此外,将所需的纳米复合材料用于生物学研究,例如通过DPPH自由基清除测试进行抗氧化剂测定。随后,由于在DPPH分析中显示出良好的IC 50值,我们扩展了Fe 3 O 4的生物应用。/ Pectin / Au使用三种癌细胞系PC-14,LC-2 / ad和HLC-1和正常细胞系HUVEC对人肺腺癌细胞进行抗癌研究。在具有最低IC 50值的PC-14细胞系中获得了最佳结果。

更新日期:2020-09-20
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