A series of organoselenium compounds based on the hybridization of nonsteroidal antiinflammatory drugs (NSAIDs) scaffolds and Se functionalities (-SeCN and -SeCF₃) were synthesized and characterized, and evaluated against four types of cancer cell lines, SW480 (human colon adenocarcinoma cells), HeLa (human cervical cancer cells), A549 (human lung carcinoma cells), MCF-7 (human breast adenocarcinoma cells). Interestingly, most of the investigated compounds showed active in reducing the viability of different cancer cell lines. The most active compound 3h showed IC₅₀ values lower than 20 μM against the four cancer cell lines, particularly to SW480 and MCF-7 with IC 50 values of 4.9 and 3.4 μM, respectively. Furthermore, NSAIDs-SeCN derivatives (2h and 2i) and NSAIDs-SeCF₃ derivatives (3h and 3i) were selected to investigate their ability to induce apoptosis in MCF-7 cells via modulation the expression of anti-apoptotic Bcl-2 protein, pro-inflammatory cytokines (IL-2) and proapoptotic caspase-3 protein. Moreover, the redox properties of the synthesized organoselenium candidates were conducted by 2, 2-didiphenyl-1-picrylhydrazyl (DPPH), bleomycin dependent DNA damage and glutathione peroxidase (GPx)-like assays. Taken together, these NSAIDs-Se candidates could provide promising new lead derivatives for further potential anticancer drug development.

合成并表征了一系列基于非甾体抗炎药（NSAIDs）支架和Se功能（-SeCN和-SeCF ₃）杂交的有机硒化合物，并针对四种类型的癌细胞系SW480（人结肠腺癌细胞）进行了评估。 ，HeLa（人宫颈癌细胞），A549（人肺癌细胞），MCF-7（人乳腺癌细胞）。有趣的是，大多数被研究的化合物在降低不同癌细胞系的生存力方面表现出活性。最具活性的化合物3h对四种癌细胞系的IC ₅₀值低于20μM，特别是对SW480和MCF-7而言，IC 50值分别为4.9和3.4μM。此外，NSAIDs-SeCN衍生物（2h和2i）和NSAIDs-SeCF ₃衍生物（3h和3i）被选择来研究其通过调节抗凋亡Bcl-2蛋白，促炎细胞因子（IL-2）的表达来诱导MCF-7细胞凋亡的能力。和凋亡的caspase-3蛋白 此外，合成的有机硒候选物的氧化还原特性是通过2、2-二联苯基-1-吡啶并肼基（DPPH），博来霉素依赖性DNA损伤和谷胱甘肽过氧化物酶（GPx）样测定进行的。总而言之，这些NSAIDs-Se候选物可以为新的潜在抗癌药物开发提供有希望的新的铅衍生物。