Microplastics (MPs) pollution in the ocean is an area of growing concern. Marine fauna subject to MPs exposure from various environmental sources are most likely to have detrimental effects on their immune system. However, studies of potential risks of MPs on marine ecosystems in light of environmental concentrations are largely limited. To this end, we presented an approach for assessing potential impact of MPs on marine ecosystems based on marine mussel Mytilus-based probabilistic risk assessment framework. The immunotoxic-based biomarkers of Mytilus were used to assess the impact of MPs on marine environment appraised with datasets by compiling oceanic region-specific and comprehensive MPs−environment studies along with published toxicity experiments. The immunological effects of MPs on lysosomal destabilization and phagocytosis in hemocytes of Mytilus were reconstructed as the concentration–response functions. We assessed the risk for marine environment exceeding a threshold of Mytilus-based immunological toxicity based on the benchmark concentration (BMC) approach corresponding to a 10% inhibition effect (BMC₁₀). We estimated BMC₁₀ values for inhibitions of lysosomal membrane stability and phagocytosis to be 1.4 and 0.4 mg L⁻¹, respectively. Here we showed that the overall MPs-associated impact potential was low among South Pacific Ocean, Mediterranean Sea, and South Atlantic Ocean. However, we found that MPs from North Pacific Ocean were very likely (>90% probability) to pose a potential threat to marine mussels. Our findings have important implications for understanding the linked relationships between environmental MPs and likelihood of exposure risk for marine organisms in different oceanic regions around the world. We suggest that Mytilus-based risk indicator for estimating risk metrics of essential marine ecosystems posed by environmentally relevant MPs concentrations can help inform practices for the sustainable management and for mitigating the environmental MPs-induced negative impact on marine organisms.

海洋中的微塑料（MPs）污染是一个日益引起人们关注的领域。受到来自各种环境源的MPs照射的海洋动物最有可能对其免疫系统产生有害影响。然而，鉴于环境集中度，关于海洋环境中海洋生物的潜在风险的研究非常有限。为此，我们提出了一种基于海洋贻贝基于Mytilus的概率风险评估框架来评估MP对海洋生态系统的潜在影响的方法。Mytilus的基于免疫毒性的生物标记通过汇编特定于海洋的海洋区域和全面的MPs环境研究以及已发表的毒性实验，通过数据集评估了MPs对海洋环境的影响。MPs对Mytilus血细胞溶酶体失稳和吞噬作用的免疫作用被重建为浓度-反应功能。我们评估了海洋环境超过的阈值的风险紫为基础的免疫毒性基于对应于10％的抑制作用（BMC基准浓度（BMC）方法₁₀）。我们估计溶酶体膜稳定性和吞噬作用的BMC ₁₀值分别为1.4和0.4 mg L ^-1， 分别。在这里，我们表明在南太平洋，地中海和南大西洋中，与MP相关的总体影响潜力较低。但是，我们发现北太平洋的国会议员极有可能（> 90％概率）对海洋贻贝构成潜在威胁。我们的发现对理解环境国会议员与世界不同海洋区域海洋生物的暴露风险可能性之间的联系关系具有重要意义。我们建议基于Mytilus的风险指标用于估算与环境相关的MP浓度所构成的基本海洋生态系统的风险指标，可以帮助为可持续管理和减轻环境MP引起的对海洋生物的负面影响提供依据。