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Male fetal sex is associated with low maternal plasma anti-inflammatory cytokine profile in the first trimester of healthy pregnancies
Cytokine ( IF 3.7 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.cyto.2020.155290
David Ramiro-Cortijo 1 , María de la Calle 2 , Rainer Böger 3 , Juliane Hannemann 3 , Nicole Lüneburg 4 , María Rosario López-Giménez 5 , Pilar Rodríguez-Rodríguez 1 , María Ángeles Martín-Cabrejas 6 , Vanesa Benítez 6 , Ángel Luis López de Pablo 1 , María Del Carmen González 1 , Silvia M Arribas 1
Affiliation  

Male fetal sex associates with higher rates of materno-fetal complications. Inflammation and inadequate vasoactive responses are mechanisms implicated in obstetric complications, and alterations in maternal plasma cytokine profile and nitric oxide (NO) metabolites are potential predictive biomarkers. We aimed to assess if these parameters are influenced by fetal sex. A prospective, observational study was carried out in 85 healthy pregnant women with singleton pregnancies in the first trimester of gestation. A blood sample was extracted at the tenth week of gestation. In plasma, we assessed: 1) cytokines (micro-array): pro-inflammatory (IL1α, IL1 β, IL6, TNFα), anti-inflammatory (IL4, IL10, IL13), and chemoattractant (IL8, MCP1, IFNγ), and 2) NO metabolites (liquid chromatography-tandem mass spectrometry and Griess reaction): L-arginine, ADMA, SDMA, nitrates (NOx). Women with a male fetus (n = 50) exhibited, compared with those with a female (n = 35): higher IL1β (OR = 1.09 with 95% CI: 0.97-1.28), and lower IL13 (OR = 0.93 with 95% CI: 0.87-0.99), and higher plasma NOx (OR = 1.14 with 95% CI: 1.03-1.31). Our data suggest that fetal sex influences maternal plasma cytokine profile and NO in early pregnancy. Women with a male fetus may have a worse capacity to counteract an inflammatory response. They may have better vasodilator capacity, but in the presence of an oxidative environment, a higher nitrosative damage may occur. These data reinforce the need to include sex as variable in predictive models.

中文翻译:

男性胎儿性别与健康妊娠头三个月的母体血浆抗炎细胞因子谱低有关

男性胎儿性别与较高的母胎并发症发生率相关。炎症和血管活性反应不足是与产科并发症有关的机制,母体血浆细胞因子谱和一氧化氮 (NO) 代谢物的改变是潜在的预测生物标志物。我们旨在评估这些参数是否受胎儿性别的影响。一项前瞻性、观察性研究在 85 名妊娠头三个月单胎妊娠的健康孕妇中进行。在妊娠第十周抽取血样。在血浆中,我们评估了:1) 细胞因子(微阵列):促炎(IL1α、IL1 β、IL6、TNFα)、抗炎(IL4、IL10、IL13)和趋化剂(IL8、MCP1、IFNγ), 2) NO 代谢物(液相色谱-串联质谱和 Griess 反应):L-精氨酸、ADMA、SDMA,硝酸盐(NOx)。与有女性胎儿的女性(n = 35)相比,有男性胎儿的女性(n = 50)表现出更高的 IL1β(OR = 1.09,95% CI:0.97-1.28)和更低的 IL13(OR = 0.93,95% CI:0.87-0.99)和更高的血浆 NOx(OR = 1.14,95% CI:1.03-1.31)。我们的数据表明,胎儿性别会影响妊娠早期母体血浆细胞因子谱和 NO。怀有男性胎儿的女性抵抗炎症反应的能力可能较差。它们可能具有更好的血管扩张能力,但在氧化环境的存在下,可能会发生更高的亚硝化损伤。这些数据强化了在预测模型中将性别作为变量的必要性。93 与 95% CI:0.87-0.99)和更高的血浆 NOx(OR = 1.14,95% CI:1.03-1.31)。我们的数据表明,胎儿性别会影响妊娠早期母体血浆细胞因子谱和 NO。怀有男性胎儿的女性抵抗炎症反应的能力可能较差。它们可能具有更好的血管扩张能力,但在氧化环境的存在下,可能会发生更高的亚硝化损伤。这些数据强化了在预测模型中将性别作为变量的必要性。93 与 95% CI:0.87-0.99)和更高的血浆 NOx(OR = 1.14,95% CI:1.03-1.31)。我们的数据表明,胎儿性别会影响妊娠早期母体血浆细胞因子谱和 NO。怀有男性胎儿的女性抵抗炎症反应的能力可能较差。它们可能具有更好的血管扩张能力,但在氧化环境的存在下,可能会发生更高的亚硝化损伤。这些数据强化了在预测模型中将性别作为变量的必要性。可能会发生更高的亚硝化损害。这些数据强化了在预测模型中将性别作为变量的必要性。可能会发生更高的亚硝化损害。这些数据强化了在预测模型中将性别作为变量的必要性。
更新日期:2020-12-01
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